Publications by authors named "Thomas B Grydeland"
Beta2-adrenoreceptor agonists and long-term risk of Parkinson's disease.
Parkinsonism Relat Disord
May 2023
Article Synopsis
- There is limited research on how different types of beta2-adrenoreceptor (β2AR) agonists impact the risk of developing Parkinson's disease in various groups of patients.
- A prospective study in Norway found that exposure to short-, long-, and ultra-long-acting β2AR agonists was linked to a lower risk of Parkinson's disease, with ultraLABA showing the strongest protective effect.
- After adjusting for factors like education and comorbidities, β2AR agonists remained inversely associated with Parkinson's risk, unlike other similar medications, indicating the need for more studies on these drugs.
Background: Decreased diffusing capacity of the lung for carbon monoxide (DLCO) is associated with emphysema. DLCO is also related to decreased arterial oxygen tension (PaO2), but there are limited data on associations between PaO2 and computed tomography (CT) derived measures of emphysema and airway wall thickness.
Objective: To examine whether CT measures of emphysema and airway wall thickness are associated with level of arterial oxygen tension beyond that provided by measurements of diffusion capacity and spirometry.
Rationale: Low educational attainment is a risk factor of chronic obstructive pulmonary disease (COPD). There is limited knowledge on the relationship between educational level and computed tomography measures of emphysema and airway wall thickness (AWT).
Objectives: We hypothesized that low educational attainment is associated with increased emphysema and AWT in ever-smokers with and without COPD.
Rationale: There is limited knowledge of the prognostic value of quantitative computed tomography (CT) measures of emphysema and airway wall thickness (AWT) on mortality.
Objectives: To examine 8-year mortality in relation to CT-measured emphysema and AWT, and assess if potential impact of these predictors remained after adjustment for lung function.
Methods: In the Norwegian GenKOLS study of 2003-2005, 947 ever-smokers (49% with COPD) aged 40-85 years performed spirometry and CT examination.
The objective of the present study was to determine the association between CT phenotypes-emphysema by low attenuation area and bronchitis by airway wall thickness-and body composition parameters in a large cohort of subjects with and without COPD. In 452 COPD subjects and 459 subjects without COPD, CT scans were performed to determine emphysema (%LAA), airway wall thickness (AWT-Pi10), and lung mass. Muscle wasting based on FFMI was assessed by bioelectrical impedance.
View Article and Find Full Text PDFUnlabelled: There is limited knowledge on the relationship between diffusing capacity of the lung for carbon monoxide (D(L)CO) and quantitative computed tomography (CT) measures of emphysema and airway wall thickness.
Study Question: What is the relationship between D(L)CO and the quantitative CT measures of emphysema and airway wall thickness in subjects with and without COPD?
Methods: We included 288 COPD subjects (70% men) and 425 non-COPD subjects (54% men). All subjects were current or ex-smokers older than 40 years and all subjects underwent spirometry, diffusing capacity tests and CT examination.
Introduction: Sampling is regarded as crucial to the validity of case-control studies. Ideally, cases and controls should be selected from the same source population, but deviations from this approach are often seen.
Objective: Our objective was to examine how exposure-disease relationships in a study on chronic obstructive pulmonary disease (COPD) were affected by the sampling sources of cases and controls.
Rationale: There is limited knowledge about the relationship between respiratory symptoms and quantitative high-resolution computed tomography measures of emphysema and airway wall thickness.
Objectives: To describe the ability of these measures of emphysema and airway wall thickness to predict respiratory symptoms in subjects with and without chronic obstructive pulmonary disease (COPD).
Methods: We included 463 subjects with chronic obstructive pulmonary disease (COPD) (65% men) and 488 subjects without COPD (53% men).
[Instructing patients in the correct use of inhalation devices].
Tidsskr Nor Laegeforen
January 2006
Background: Limited knowledge is available on to what extent doctors and nurses know the correct use of various inhalation devices. We wanted to examine this skill among 25 doctors and 25 nurses randomly selected from the departments of pulmonology, internal medicine and surgery at a university hospital.
Design: Two technicians asked them to demonstrate the correct use of a metered-dose inhaler (MDI), Turbuhaler and Diskus.