Publications by authors named "Thomas B Gallen"
Complete aortic valve fusion after HeartMate II left ventricular assist device support.
J Cardiothorac Vasc Anesth
December 2012
Analysis of pulmonary vasodilator responses to the Rho-kinase inhibitor fasudil in the anesthetized rat.
Am J Physiol Lung Cell Mol Physiol
November 2008
The small GTP-binding protein Rho and its downstream effector, Rho-kinase, are important regulators of vasoconstrictor tone. Rho-kinase is upregulated in experimental models of pulmonary hypertension, and Rho-kinase inhibitors decrease pulmonary arterial pressure in rodents with monocrotaline and chronic hypoxia-induced pulmonary hypertension. However, less is known about responses to fasudil when pulmonary vascular resistance is elevated on an acute basis by vasoconstrictor agents and ventilatory hypoxia.
View Article and Find Full Text PDFRho kinase and Ca2+ entry mediate increased pulmonary and systemic vascular resistance in L-NAME-treated rats.
Am J Physiol Lung Cell Mol Physiol
November 2007
Article Synopsis
- Rho kinase plays a crucial role in regulating blood vessel constriction in the lungs, especially in conditions with low oxygen levels.
- When the NO synthesis is inhibited, Rho kinase activation leads to increased vascular resistance.
- In experiments with intact rats, using the Rho kinase inhibitor fasudil showed that it decreased blood pressure and increased heart output, particularly after NO inhibition, confirming its role in mediating vascular responses.