Publications by authors named "Thomas B Fanthom"
J Pharm Sci
December 2023
Article Synopsis
- Peristaltic pumping can lead to loss and aggregation of therapeutic proteins due to complex interactions in the pump system.
- Researchers developed methods to isolate different pump mechanisms to study their effects on protein monomer loss.
- Key findings reveal that pump speed and tubing compression (occlusion) significantly influence protein loss, with solid-solid contact between tubing walls being the major factor contributing to this issue.
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