Simple finite element models for use in the design of therapeutic footwear.

Therapeutic footwear is frequently prescribed in cases of rheumatoid arthritis and diabetes to relieve or redistribute high plantar pressures in the region of the metatarsal heads. Few guidelines exist as to how these interventions should be designed and what effect such interventions actually have on the plantar pressure distribution. Finite element analysis has the potential to assist in the design process by refining a given intervention or identifying an optimal intervention without having to actually build and test each condition.

Optimization of nonlinear hyperelastic coefficients for foot tissues using a magnetic resonance imaging deformation experiment.

Accurate prediction of plantar shear stress and internal stress in the soft tissue layers of the foot using finite element models would provide valuable insight into the mechanical etiology of neuropathic foot ulcers. Accurate prediction of the internal stress distribution using finite element models requires that realistic descriptions of the material properties of the soft tissues are incorporated into the model. Our investigation focused on the creation of a novel three-dimensional (3D) finite element model of the forefoot with multiple soft tissue layers (skin, fat pad, and muscle) and the development of an inverse finite element procedure that would allow for the optimization of the nonlinear elastic coefficients used to define the material properties of the skin muscle and fat pad tissue layers of the forefoot based on a Ogden hyperelastic constitutive model.

Modeling physiology of the urinary tract.

We review mathematical and physical models of physiology of the organs of the urinary tract and their functions of producing, excreting, and voiding urine. Models for urine concentration in the kidney, urine flow in the ureters, bladder filling and emptying, urethral function during micturition, pelvic floor muscles, and neural control are reviewed in the context of their application to the development of new diagnostic and therapeutic techniques. The focus of this review is on modeling of physiology and function at the tissue and organ level, as almost all research to date has been done in those areas.