Biochip array technology immunoassay performance and quantitative confirmation of designer piperazines for urine workplace drug testing.

Designer piperazines are emerging novel psychoactive substances (NPS) with few high-throughput screening methods for their identification. We evaluated a biochip array technology (BAT) immunoassay for phenylpiperazines (PNP) and benzylpiperazines (BZP) and analyzed 20,017 randomly collected urine workplace specimens. Immunoassay performance at recommended cutoffs was evaluated for PNPI (5 μg/L), PNPII (7.

The emergence of sex differences in personality traits in early adolescence: A cross-sectional, cross-cultural study.

Although large international studies have found consistent patterns of sex differences in personality traits among adults (i.e., women scoring higher on most facets), less is known about cross-cultural sex differences in adolescent personality and the role of culture and age in shaping them.

The Inaccuracy of National Character Stereotypes.

Consensual stereotypes of some groups are relatively accurate, whereas others are not. Previous work suggesting that national character stereotypes are inaccurate has been criticized on several grounds. In this article we (a) provide arguments for the validity of assessed national mean trait levels as criteria for evaluating stereotype accuracy; and (b) report new data on national character in 26 cultures from descriptions (=3,323) of the typical male or female adolescent, adult, or old person in each.

Stereotypes of age differences in personality traits: universal and accurate?

Age trajectories for personality traits are known to be similar across cultures. To address whether stereotypes of age groups reflect these age-related changes in personality, we asked participants in 26 countries (N = 3,323) to rate typical adolescents, adults, and old persons in their own country. Raters across nations tended to share similar beliefs about different age groups; adolescents were seen as impulsive, rebellious, undisciplined, preferring excitement and novelty, whereas old people were consistently considered lower on impulsivity, activity, antagonism, and Openness.

Comparison of the photochemistry of organometallic N-heterocyclic carbene and phosphine complexes of manganese.

Time-resolved IR (TRIR) studies on (η(5)-C(5)H(4)Me)Mn(L)(CO) (L = 1,3-diethyl-4,5-dimethylimidazol-2-ylidene, PPh(3)) indicate that the rate of reaction with CO is ca. 10(2) slower for the N-heterocyclic carbene intermediate, which DFT calculations suggest is due to the presence of a strong MnH-C agostic bond. The reactivity of these intermediates in alkane solvents is governed by such interactions rather than solvent coordination to the unsaturated metal centre.

Perceptions of aging across 26 cultures and their culture-level associates.

College students (N=3,435) in 26 cultures reported their perceptions of age-related changes in physical, cognitive, and socioemotional areas of functioning and rated societal views of aging within their culture. There was widespread cross-cultural consensus regarding the expected direction of aging trajectories with (a) perceived declines in societal views of aging, physical attractiveness, the ability to perform everyday tasks, and new learning; (b) perceived increases in wisdom, knowledge, and received respect; and (c) perceived stability in family authority and life satisfaction. Cross-cultural variations in aging perceptions were associated with culture-level indicators of population aging, education levels, values, and national character stereotypes.

Ethical considerations in geriatric neuropsychology.

The practice of geriatric neuropsychology demands specialized training and experience that enables the practitioner to appreciate the unique challenges and opportunities that are encountered when working with older adults. In addition to maintaining advanced knowledge regarding medical and psychological conditions, assessment issues, and treatment needs specific to older persons, clinicians working with older adults must be prepared to recognize and confront ethical dilemmas that arise. For example, ethical challenges related to professional competence, informed consent, assessment, and privacy and confidentiality may be prominent when working with older persons.

Testosterone levels among men with spinal cord injury: relationship between time since injury and laboratory values.

Objectives: The objectives of the present study were to determine the prevalence of low testosterone among a sample of men with spinal cord injury and to examine the relationship among testosterone, time since injury, and select laboratory values.

Design: Participants were 102 men with spinal cord injury participating in inpatient or outpatient rehabilitation. Data included total serum testosterone level, demographic and injury information, and laboratory values.

Personality trait similarity between spouses in four cultures.

We examined patterns of trait similarity (assortative mating) in married couples in four cultures, using both self-reports and spouse ratings on versions of the Revised NEO Personality Inventory. There was evidence of a subtle but pervasive perceived contrast bias in the spouse-rating data. However, there was strong agreement across methods of assessment and moderate agreement across cultures in the pattern of results.

The ethical and clinical practice of disclosing raw test data: addressing the ongoing debate.

Neuropsychologists are prone to having raw test data requested by colleagues, clients, and attorneys. Although questions of when and to whom neuropsychologists should release raw test data have been debated for years, uncertainty about how to address requests for raw test data persists. Although contradictions within and between ethical and legal guidelines exist, general bioethical principles, most ethical and professional guidelines, and federal copyright law support the responsibility of practitioners to maintain the security of neuropsychological tests, including raw test data.

Age trends and age norms for the NEO Personality Inventory-3 in adolescents and adults.

The NEO Personality Inventory-3 (NEO-PI-3) is a modification of the Revised NEO Personality Inventory (NEO-PI-R) designed to be more understandable to adolescents. Data from adults aged 21 to 91 showed that the NEO-PI-3 also functions as well or better than the NEO-PI-R in adults. Age trends from combined adolescent (n = 500) and adult (n = 635) samples confirmed previous cross-sectional findings and demonstrated the importance of studying age changes especially at the facet level and during the decade of the 20s.

The NEO-PI-3: a more readable revised NEO Personality Inventory.

Use of the Revised NEO Personality Inventory (NEO-PI-R; Costa & McCrae, 1992) in adolescent samples has shown that a few respondents have difficulty with a subset of items. We identified 30 items that were not understood by at least 2% of adolescent respondents and 18 additional items with low item-total correlations, and we wrote 2 trial replacement items for each. We used self-report and observer rating data from 500 respondents aged 14 to 20 to select replacement items.

Traumatic brain injury and Alzheimer's: deficit profile similarities and the impact of normal ageing.

Research has suggested that sustaining a traumatic brain injury (TBI) may increase one's risk of developing Dementia of the Alzheimer's Type (DAT) later in life. Several neuropathological models have been proposed to explain the association between TBI and DAT and studies using a neuropsychological deficit profile methodology suggest that the pattern and extent of cognitive decline associated with these conditions are similar. This paper presents a new conceptual model, derived from deficit profile methodology, regarding the relationship between TBI and DAT.

Clinical utility of the trail making test ratio score.

It has been suggested that a ratio score of part B to part A of the Trail Making Test (TMT) may have clinical utility as a measure of cognitive efficiency and/or dissimulation. We investigated the clinical utility of the TMT B/A ratio score in the evaluation of patients with traumatic brain injury. Part B of the TMT demonstrated a statistically significant difference between groups with mild (n = 59) versus moderate-severe (n = 41) injuries.

Cognitive decline over time following electrical injury.

Electrical injury (EI) is on the rise in the US, with more than 2400 injuries occurring annually. Consequences of EI often include diffuse neurological damage and a myriad of emotional and behavioural sequelae. While delayed onset of cognitive dysfunction is frequently alluded to in the literature, few cases have been published that document the progressive neuropsychological manifestations of EI over time.