Publications by authors named "Thomas A Kovesi"
Article Synopsis
- * Current management guidelines mainly focus on childhood, but there's a lack of structured care for patients transitioning into adulthood, prompting the need for new guidelines.
- * The Transition Working Group of the International Network on Oesophageal Atresia developed 42 evidence-based recommendations for managing EA-TEF complications during the transition from adolescence to adulthood, based on a comprehensive literature review and expert consensus.
Background: Primary ciliary dyskinesia (PCD) is typically an autosomal recessive disease characterized by recurrent infections of the lower respiratory tract, frequent and severe otitis media, chronic rhinosinusitis, neonatal respiratory distress, and organ laterality defects. While severe lower respiratory tract infections and bronchiectasis are common in Inuit, PCD has not been recognized in this population.
Methods: We report a case series of seven Inuit patients with PCD identified by genetic testing in three Canadian PCD centers.
Bronchiectasis in children from Qikiqtani (Baffin) Region, Nunavut, Canada.
Ann Am Thorac Soc
January 2015
Rationale: Bronchiectasis not related to cystic fibrosis is common in indigenous populations globally, but it has not been studied in Canadian indigenous children.
Objective: The objective of this study was to describe bronchiectasis in Canadian Inuit children and examine potentially causal factors.
Methods: We described the clinical features of bronchiectasis in Canadian Inuit children residing in the Qikiqtani (Baffin) Region, Nunavut, Canada, by performing a retrospective chart review of children from this region.
Background: Inuit children in Nunavut, Canada, have high rates of lower respiratory tract infection (LRTI) early in life. Whether this commonly results in chronic respiratory symptoms later in life is unknown.
Methods: A cross-sectional survey of 3- to 5-years-old Inuit children was conducted in all three regions of Nunavut, as part of the "Qanuippitali, what about us, how are we?" survey.
Background: Adrenal suppression secondary to high-dose inhaled corticosteroid use has been reported in children.
Methods: The authors report the use of ciclesonide to reverse adrenal suppression secondary to inhaled fluticasone use in four pediatric patients.
Results: In these four children, hypothalamic-pituitary-adrenal axis function normalized after the patients were changed to ciclesonide, while good asthma control was maintained.
Background: The fractional concentration of exhaled nitric oxide (FeNO) appears to be a good marker for airway inflammation in children with asthma.
Objective: To evaluate the effect of environmental exposures on exhaled nitric oxide in a community sample of children.
Methods: The relationship among exhaled nitric oxide, underlying disease and home environmental exposures was examined using questionnaire data and measurement of exhaled nitric oxide in a cross-sectional study of 1135 children that included healthy children, and children with allergies and/or asthma who were attending grades 4 through 6 in Windsor, Ontario.