Publications by authors named "Thomas A Charlton"
Article Synopsis
- Fructose metabolism is linked to several diseases, but a lack of suitable imaging tools has made studying its role in these conditions difficult.
- Researchers developed a new radiotracer, [F]4-FDF, using a molecular design inspired by aldolase, an enzyme crucial for fructose breakdown, achieving high effectiveness in metabolic imaging.
- The study found that [F]4-FDF has low uptake in healthy brain and heart tissues while successfully mapping inflammatory responses, indicating its potential as a valuable tool for diagnosing fructose metabolism-related diseases.
A concise, easily scalable synthesis of a rare ketohexose, d-tagatose, was developed, that is compatible with the preparation of d-[UL-C]tagatose. Epimerization of the widely available and inexpensive ketohexose d-fructose at the C-4 position via an oxidation/reduction (Dess-Martin periodinane/NaBH) was a key step in the synthesis. Overall, fully protected natural d-tagatose (3.
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