Publications by authors named "Thom DO"

Article Synopsis
  • Current chemical drugs are ineffective for tick control and there are no effective vaccines, leading to the urgent need for new control strategies.
  • Small interfering RNAs (siRNAs) have potential to help control parasites, but their effectiveness is limited by challenges in getting them to the RNA-induced silencing complex (RISC).
  • This study developed a delivery system using chitosan nanoparticles to successfully transfect siRNAs into parasites, which reduced target gene expression and inhibited parasite growth, opening new avenues for gene therapy and understanding host-parasite interactions.
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In Egypt, camel trypanosomiasis is widespread. From October 2021 to March 2022, we collected 181 blood samples from apparently healthy one-humped camels (Camelus dromedarius) in Cairo and Giza Governates. The objective of this study was to assess infection rates of trypanosomes using blood smear examination and PCR-sequencing assays.

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Dog owners are greatly concerned about tick infestations in their pets. The prevalence and dispersion of ticks and their disease-causing microorganisms have been limited from the viewpoint of dog owners in Vietnam. This study investigated the presence of tick infestation and the pathogens associated with it in canines that were brought to veterinary hospitals in Vietnam.

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Article Synopsis
  • Piroplasmosis is a tick-borne disease impacting livestock like camels, caused by parasites from the order Piroplasmida, with limited research on this issue in Egypt.
  • A study involving 181 blood samples from camels in Cairo and Giza found a 41.4% infection rate, identifying several piroplasmid species, including B. bovis, B. bigemina, and a first detection of T. equi genotype E in Egypt.
  • The research highlights the need for effective control strategies against piroplasmosis, particularly concerning B. microti, which poses potential risks to human health.
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Malaria remains one of the most significant health issues worldwide, accounting for 2.6% of the total global disease burden, and efforts to eliminate this threat continue. The key focus is to develop an efficient and long-term immunity to this disease via vaccination or therapeutic approach, and innovative strategies would enable us to achieve this target.

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Babesia gibsoni is mainly transmitted by hard ticks of the genus Rhipicephalus (R. sanguineus) and Haemaphysalis (H. longicornis), and causes canine babesiosis.

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Babesia gibsoni is an intraerythrocytic apicomplexan parasite transmitted by Haemaphysalis longicornis and causes canine babesiosis. Within the tick, the Babesia parasite undergoes sexual conjugation and the sporogony process of its life cycle. To control B.

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Fleas are considered as hosts for a wide range of pathogens that cause emerging and re-emerging zoonotic diseases worldwide. Data on fleas and flea-borne pathogens (FBPs) in the international literature are limited in Vietnam. This study aimed to investigate the species of fleas and the presence of pathogens of interest in fleas in northern Vietnam using PCR and sequence analysis.

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Article Synopsis
  • * Blood samples from 174 stray dogs in Songkhla and Narathiwat provinces were analyzed for canine vector-borne pathogens using various genetic testing methods, revealing several types of infections.
  • * The study marks the first molecular detection and genetic analysis of these pathogens in stray dogs in Thailand, emphasizing the need for further research on their origins and impact on zoonotic diseases.
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Canine tick-borne pathogens (CTBPs) such as , , , and are important pathogens in dogs worldwide. sensu lato, the main vector of several CTBPs, is the most common tick species found on dogs in Thailand. The present study identified CTBPs in dogs and ticks infested dogs.

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Background: Cats can be carriers of infected arthropods and be infected with several vector-borne pathogens (VBPs) but there is limited knowledge about their pathogenic role in cats. This study aimed to assess the prevalence of some feline vector-borne agents by molecular technique and to characterize the hematological findings associated with these infections in a cat population from Bangkok Thailand.

Results: PCR was positive with at least one pathogen in 237 out of 372 subjects (63.

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A 2.5-year-old male German Shepherd was presented to a private veterinary clinic in Hanoi, Vietnam showing anorexia, weakness, lethargy, reluctant to go for walks with a recent history of intermittent fever. Clinical examination of the dog showed pale mucous membrane, impaired eyesight, edema of the back legs.

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Background: Ticks and fleas are considered amongst the most important arthropod vectors of medical and veterinary concern due to their ability to transmit pathogens to a range of animal species including dogs, cats and humans. By sharing a common environment with humans, companion animal-associated parasitic arthropods may potentially transmit zoonotic vector-borne pathogens (VBPs). This study aimed to molecularly detect pathogens from ticks and fleas from companion dogs and cats in East and Southeast Asia.

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Article Synopsis
  • Stray cats in Thailand are linked to zoonotic diseases, including hemoplasmosis, prompting a study on this disease in semi-domesticated cats in Bangkok.
  • Researchers collected 473 blood samples from various temple communities, finding a 38% prevalence of hemoplasma, predominantly caused by Mycoplasma haemominutum in older cats.
  • The study's results, including a genetic analysis and risk factors for infection, aim to inform strategies for preventing and controlling infections from feline diseases in Thailand.
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A refined simple first-order shear deformation theory is developed to investigate the static bending and free vibration of advanced composite plates such as functionally graded plates. By introducing the new distribution shape function, the transverse shear strain and shear stress have a parabolic distribution across the thickness of the plates, and they equal zero at the surfaces of the plates. Hence, the new refined theory needs no shear correction factor.

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In this paper, a 2-node beam element is developed based on Quasi-3D beam theory and mixed formulation for static bending of functionally graded (FG) beams. The transverse shear strains and stresses of the proposed beam element are parabolic distributions through the thickness of the beam and the transverse shear stresses on the top and bottom surfaces of the beam vanish. The proposed beam element is free of shear-looking without selective or reduced integration.

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In working processes, mechanical systems are often affected by both internal and external forces, which are the cause of the forced vibrations of the structures. They can be destroyed if the amplitude of vibration reaches a high enough value. One of the most popular ways to reduce these forced vibrations is to attach tuned mass damper (TMD) devices, which are commonly added at the maximum displacement point of the structures.

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This paper presents a finite element formulation to study the mechanical buckling of stiffened functionally graded material (FGM) plates. The approach is based on a third-order shear deformation theory (TSDT) introduced by Guangyu Shi. The material properties of the plate were assumed to be varied in the thickness direction by a power law distribution, but the material of the stiffener was the same as that of the one of the bottom surface where the stiffener was placed.

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Triple-layered composite plates are created by joining three composite layers using shear connectors. These layers, which are assumed to be always in contact and able to move relatively to each other during deformation, could be the same or different in geometric dimensions and material. They are applied in various engineering fields such as ship-building, aircraft wing manufacturing, etc.

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There are many beam models to simulate the variable thickness functionally graded material (FGM) beam, each model has advantages and disadvantages in computer aided engineering of the mechanical behavior of this beam. In this work, a new model of beam is presented to study the mechanical static bending, free vibration, and buckling behavior of the variable thickness functionally graded material beams. The formulations are based on modified first order shear deformation theory and interpolating polynomials.

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