Bioactive abietenolide diterpenes from Suregada procera.

The phytochemical investigation of the leaves and the roots of Suregada procera afforded the new ent-abietane diterpenoid sureproceriolide A (1) along with the known secondary metabolites 8,14β:11,12α-diepoxy-13(15)-abietane-16,12-olid (2), jolkinolide A (3), jolkinolide E (4), ent-pimara-8(14),15-dien-19-oic acid (5), sitosterol (6), oleana-9(11):12-dien-3β-ol (7), and oleic acid (8). Their structures were elucidated by NMR spectroscopic and mass spectrometric analyses, and the structure of jolkinolide A (3) was confirmed by single-crystal X-ray diffraction analysis. Sureproceriolide A (1) showed modest activity against the Gram-positive bacterium Staphylococcus lugdunensis (MIC = 31.

Modified -Abietane Diterpenoids from the Leaves of .

The leaf extract of gave two new modified -abietane diterpenoids, zanzibariolides A () and B (), and two known triterpenoids, simiarenol () and β-amyrin (). The structures of the isolated compounds were elucidated based on NMR and MS data analysis. Single-crystal X-ray diffraction was used to establish the absolute configurations of compounds and .

Antibacterial and cytotoxic biflavonoids from the root bark of Ochna kirkii.

The new isoflavonoid kirkinone A (1) and biflavonoid kirkinone B (2) along with six known compounds (3-8) were isolated from the methanolic extract of the root bark of Ochna kirkii. The compounds were identified by NMR spectroscopic and mass spectrometric analyses. Out of the eight isolated natural products, calodenin B (4) and lophirone A (6) showed significant antibacterial activity against the Gram-positive bacterium Bacillus subtilis with MIC values of 2.

Biflavanones, Chalconoids, and Flavonoid Analogues from the Stem Bark of .

Two new biflavanones ( and ), three new bichalconoids (-), and 11 known flavonoid analogues (-) were isolated from the stem bark extract (CHOH-CHCl, 7:3, v/v) of . The structures of the isolated metabolites were elucidated by NMR spectroscopic and mass spectrometric analyses. The crude extract and the isolated metabolites were evaluated for antibacterial activity against (Gram-positive) and (Gram-negative) as well as for cytotoxicity against the MCF-7 human breast cancer cell line.