and hybrid approach to unveil triterpenoids from leaves as potential compounds for inhibiting Nrf2.

Cancer is a leading global health concern, with over 20 million new cases and 9.7 million deaths reported in 2022. Chemotherapy remains a widely used treatment, but drug resistance, which affects up to 90% of treatment outcomes, significantly hampers its effectiveness.

In Vitro Biological Evaluation and In Silico Studies of a New Anthraquinone From Zingiber Cassumunar Roxb. in Type 2 Diabetes Management.

A novel diphenyl-anthraquinone compound, cassuquinone A (CA), was isolated from the rhizomes of Zingiber cassumunar. Structural elucidation was accomplished using detailed nuclear magnetic resonance and high-resolution mass spectroscopy-electrospray ionization techniques, revealing a symmetrical anthraquinone core with methoxylated aromatic rings. CA exhibited potent α-glucosidase (AR) inhibitory activity with an IC₅₀ of 11.

Three undescribed phenylbutenoids derivatives from Roxb. rhizomes and their biological activities.

Phenylbutenoids belong to polyphenolic compounds that have demonstrated distinctive biological activities and are primarily characterised in the genus Zingiber (Zingiberaceae) species. From the EtOAc extract of the rhizomes of Roxb., three phenylbutenoid-type compounds, cassudimin B (), cassumunol O (), and cassumunol P (), were isolated, along with five known compounds (-).

Discovery of Alkyl Triphenylphosphonium Pinostrobin Derivatives as Potent Anti-Breast Cancer Agents.

Pinostrobin demonstrated anticancer properties, but its hydrophobic feature led to a reduction in bioavailability. The mitochondria-targeted approach successfully synthesized eight new alkyl triphenylphosphonium pinostrobin derivatives (1-8) with good yield in this study. Seven compounds (1-3, 5-8) showed greater cytotoxic potency against the human MCF-7 breast cancer cell line than pinostrobin.

biological evaluation and studies of linear diarylheptanoids from Salisb. as urease inhibitors.

Plants of the family, specifically those belonging to the species, are commonly under consideration as potential therapeutic agents for the management of gastrointestinal diseases. In this study, we carried out a phytochemical study on Salisb. (or so-called "Nghe trang" in Vietnamese) grown in Vietnam, which yields three newly discovered 3,5-diacetoxy diarylheptanoids (1-3) and six known 3,5-dihydroxyl diarylheptanoids (4-9).

A new apotirucallane-type protolimonoid from the leaves of .

This study presents a phytochemical analysis of the leaves of , revealing the isolation of a new apotirucallane-type protolimonoid, identified as 25--methyl-1,2-dihydroprotoxylocarpin D (), along with two known compounds ( and ). The known compounds were identified as (20,21,23)-21,23-epoxy-7,24,25-trihydroxy-21--methyl-3-oxoapotirucalla-14-ene () and 7,24,25-trihydroxy-3-oxoapotirucalla-14-en-21,23-olide (). The three apotirucallane-type protolimonoids (-) did not exhibit cytotoxicity against MCF-7 cells at a concentration of 100 µM.

A novel diphenylbutenoid-type compound from the rhizomes of (J.Koenig) Link ex A.Dietr. (Zingiberaceae).

From the EtOAc-soluble extract of the rhizomes of (J.Koenig) Link ex A.Dietr.

Taxotrophises A and B, two new polyphenols from the stems of .

From the EtOAc extract of the wood of the stems of (Moraceae), two new secondary metabolites, named taxotrophises A () and B (), were isolated, together with five known compounds (-). Their chemical structures have been elucidated by extensive NMR spectroscopic analysis. All isolated compounds have been evaluated for -glucosidase inhibitory activity.

Strebluses E-H, four new stilbene-like derivatives from the stems of .

Following bioactivity-guided isolation, four new stilbene-like derivatives, named Strebluses E-H, were isolated from the EtOAc-soluble fraction of the stems of (Moraceae). Their chemical structures were elucidated based on NMR spectroscopic data interpretation and optical rotation calculation. E possesses potent tyrosinase inhibitory activity with an IC value of 0.

Two new phenylbutenoids from the rhizomes of cassumunar ginger and their -glucosidase inhibitory activity.

An extract from the rhizomes of Cassumunar ginger ( Roscoe). was found to have significant -glucosidase inhibitory activity with an IC value of 6.3 g/mL.

A New abeo-Icetexane-Type Diterpenoid from the Stem Barks of Taxus wallichiana.

From a CH Cl -soluble fraction of the stem barks of Taxus wallichiana, one new abeo-icetexane-type diterpenoid, taxamairin I (1), was isolated. Its absolute configuration was elucidated based on spectroscopic interpretation and time-dependent density functional theory (TD-DFT) calculation of optical rotation. In addition, the plausible biosynthesis pathway for the formation of the new abeo-icetexane-type diterpenoid was proposed.

Paratrimerin Z, an undescribed chromene derivative from the roots of .

From an EtOAc-soluble fraction of the roots of , one undescribed chromene derivative, paratrimerin Z (), was isolated. Its structure was elucidated on the basis of NMR spectroscopic interpretation. The absolute configuration of was determined by the specific rotation analysis of its acid-catalyzed hydrolysis product.

-Tocopherol derivatives from the leaves of L.

From an ethyl acetate-soluble fraction of the leaves of , one new trimeric -tocopherol derivative named as tocomuntin A (), together with three known -tocopherol derivatives (-) were isolated. Their structures were elucidated based on the interpretation of NMR and MS spectroscopic data. In this work, -tocopherol () was found to have -glucosidase inhibitory activity for the first time (IC, 47.

A new diphenylheptanoid from the rhizomes of .

A phytochemical investigation of the rhizomes of  was carried out, leading to the isolation of a new diphenylheptanoid, zedoaroxane A (), together with four known compounds (-). Their structures were elucidated based on NMR spectroscopic data. All isolated compounds possessed -glucosidase inhibitory activity, with the IC values ranging from 35.

Two new derivatives of 8-prenyl-5,7-dihydroxycoumarin from the stems of (S.Vidal) Corn.

From the EtOAc-soluble extract of the stems of (Moraceae), two new secondary metabolites named strebluses A () and B () were isolated. Their chemical structures have been concluded based on the chemical derivatisation and the spectroscopic interpretation. All compounds have been tested for their tyrosinase inhibitory activity.

A new 8,3'-neolignan from Lour.

The phytochemical investigation of the EtOAc-soluble fraction of the aerial parts of Lour. has been carried out to obtain seven compounds, including a new 8,3'-neolignan named solacanin A (). Their chemical structures were elucidated based on the spectroscopic data interpretation.

A new lignan from the stems of Blume (Anacardiaceae).

From the EtOAc-soluble extract of the stems of , one new lignan, (+)-(8,8')-5'-methoxy-4,4'-di--methylsecoisolariciresinol (), together with five known compounds () were isolated. Their structures were elucidated on the basis of NMR spectroscopic interpretation. The absolute configuration of was determined based on the Cotton effects in the ECD spectrum.

A new flavanone derivative from the rhizomes of .

From the methanolic extract of the rhizomes of , a new flavanone derivative named (2,7″)-8-(1-phenyl-2-carboxyethyl)pinocembrin () and four known flavonoids (-) were isolated. Its absolute configuration was concluded by NMR and MS spectroscopic analysis, together with comparison between experimental and calculated ECD data. In turn, compound exhibited strong cytotoxicity against the PANC-1 human pancreatic cancer cell line with a PC value of 6.

Decumbic anhydride from the stem barks of (Anacardiaceae).

From an EtOAc-soluble fraction of the stem barks of (Anacardiaceae), decumbic anhydride () and four known compounds - were isolated. Their chemical structures were elucidated based on the spectroscopic data interpretation. The GIAO-DFT calculation of C NMR chemical shifts was carried out to clarify the structure of .

Paratrimerin I, cytotoxic acridone alkaloid from the roots of .

Bioactivity-guided fractionation of the CHCl-soluble extract of the roots of was carried out to obtain a new acridone alkaloid, paratrimerin I. Its structure was elucidated based on NMR spectroscopic data interpretation. Paratrimerin I showed noteworthy cytotoxicity against the HepG2 human hepatocellular and MCF-7 human breast carcinoma cell lines, with the submicromolar IC values of 0.

A new phenylheptanoid from the leaves of L.

Phytochemical study on the EtOAC-soluble extract of the leaves of furnished the isolation of a new phenylheptanoid, gnetumal (), along with five known compounds (-). Their isolation was carried out by using the column chromatography and their structures were elucidated based on the basis of the spectral interpretation. Bioactivity assay of these compounds indicated that gnetumal () and -coumaric acid () possessed more potent tyrosinase inhibitory activity, with IC values of 31.

A new phenolic acid from the wood of .

From the methanol extract of the wood of (Anacardiaceae), we had isolated a new secondary metabolite named gedebic acid () and six known compounds (). Their chemical structures were determined by spectroscopic methods as well as comparing with data in the literature. All compounds were tested for -glucosidase inhibitory activity.

Chemical Constituents of Mangifera indica and Their Antiausterity Activity against the PANC-1 Human Pancreatic Cancer Cell Line.

Human pancreatic cancer cell lines such as PANC-1 have an altered metabolism, enabiling them to tolerate and survive under extreme conditions of nutrient starvation. The search for candidates that inhibit their viability during nutrition starvation represents a novel antiausterity strategy in anticancer drug discovery. A methanol extract of the bark of Mangifera indica was found to inhibit the survival of PANC-1 human pancreatic cancer cells preferentially under nutrient-deprived conditions with a PC50 value of 15.