Three undescribed phenylbutenoids derivatives from Roxb. rhizomes and their biological activities.

Phenylbutenoids belong to polyphenolic compounds that have demonstrated distinctive biological activities and are primarily characterised in the genus Zingiber (Zingiberaceae) species. From the EtOAc extract of the rhizomes of Roxb., three phenylbutenoid-type compounds, cassudimin B (), cassumunol O (), and cassumunol P (), were isolated, along with five known compounds (-).

Discovery of Alkyl Triphenylphosphonium Pinostrobin Derivatives as Potent Anti-Breast Cancer Agents.

Pinostrobin demonstrated anticancer properties, but its hydrophobic feature led to a reduction in bioavailability. The mitochondria-targeted approach successfully synthesized eight new alkyl triphenylphosphonium pinostrobin derivatives (1-8) with good yield in this study. Seven compounds (1-3, 5-8) showed greater cytotoxic potency against the human MCF-7 breast cancer cell line than pinostrobin.

biological evaluation and studies of linear diarylheptanoids from Salisb. as urease inhibitors.

Plants of the family, specifically those belonging to the species, are commonly under consideration as potential therapeutic agents for the management of gastrointestinal diseases. In this study, we carried out a phytochemical study on Salisb. (or so-called "Nghe trang" in Vietnamese) grown in Vietnam, which yields three newly discovered 3,5-diacetoxy diarylheptanoids (1-3) and six known 3,5-dihydroxyl diarylheptanoids (4-9).

A new apotirucallane-type protolimonoid from the leaves of .

This study presents a phytochemical analysis of the leaves of , revealing the isolation of a new apotirucallane-type protolimonoid, identified as 25--methyl-1,2-dihydroprotoxylocarpin D (), along with two known compounds ( and ). The known compounds were identified as (20,21,23)-21,23-epoxy-7,24,25-trihydroxy-21--methyl-3-oxoapotirucalla-14-ene () and 7,24,25-trihydroxy-3-oxoapotirucalla-14-en-21,23-olide (). The three apotirucallane-type protolimonoids (-) did not exhibit cytotoxicity against MCF-7 cells at a concentration of 100 µM.

A novel diphenylbutenoid-type compound from the rhizomes of (J.Koenig) Link ex A.Dietr. (Zingiberaceae).

From the EtOAc-soluble extract of the rhizomes of (J.Koenig) Link ex A.Dietr.

A new -carboline-type alkaloid from the flowers of (L.) W.T.Aiton.

In our antioxidant screening of some Vietnamese plant extracts, the CHCl-soluble fraction from (L.) W.T.

Taxotrophises A and B, two new polyphenols from the stems of .

From the EtOAc extract of the wood of the stems of (Moraceae), two new secondary metabolites, named taxotrophises A () and B (), were isolated, together with five known compounds (-). Their chemical structures have been elucidated by extensive NMR spectroscopic analysis. All isolated compounds have been evaluated for -glucosidase inhibitory activity.

Strebluses E-H, four new stilbene-like derivatives from the stems of .

Following bioactivity-guided isolation, four new stilbene-like derivatives, named Strebluses E-H, were isolated from the EtOAc-soluble fraction of the stems of (Moraceae). Their chemical structures were elucidated based on NMR spectroscopic data interpretation and optical rotation calculation. E possesses potent tyrosinase inhibitory activity with an IC value of 0.

Two new phenylbutenoids from the rhizomes of cassumunar ginger and their -glucosidase inhibitory activity.

An extract from the rhizomes of Cassumunar ginger ( Roscoe). was found to have significant -glucosidase inhibitory activity with an IC value of 6.3 g/mL.

A New abeo-Icetexane-Type Diterpenoid from the Stem Barks of Taxus wallichiana.

From a CH Cl -soluble fraction of the stem barks of Taxus wallichiana, one new abeo-icetexane-type diterpenoid, taxamairin I (1), was isolated. Its absolute configuration was elucidated based on spectroscopic interpretation and time-dependent density functional theory (TD-DFT) calculation of optical rotation. In addition, the plausible biosynthesis pathway for the formation of the new abeo-icetexane-type diterpenoid was proposed.

Paratrimerin Z, an undescribed chromene derivative from the roots of .

From an EtOAc-soluble fraction of the roots of , one undescribed chromene derivative, paratrimerin Z (), was isolated. Its structure was elucidated on the basis of NMR spectroscopic interpretation. The absolute configuration of was determined by the specific rotation analysis of its acid-catalyzed hydrolysis product.

-Tocopherol derivatives from the leaves of L.

From an ethyl acetate-soluble fraction of the leaves of , one new trimeric -tocopherol derivative named as tocomuntin A (), together with three known -tocopherol derivatives (-) were isolated. Their structures were elucidated based on the interpretation of NMR and MS spectroscopic data. In this work, -tocopherol () was found to have -glucosidase inhibitory activity for the first time (IC, 47.

A new diphenylheptanoid from the rhizomes of .

A phytochemical investigation of the rhizomes of  was carried out, leading to the isolation of a new diphenylheptanoid, zedoaroxane A (), together with four known compounds (-). Their structures were elucidated based on NMR spectroscopic data. All isolated compounds possessed -glucosidase inhibitory activity, with the IC values ranging from 35.

Tyrosinase Inhibitors from the Stems of .

Two new stilbene derivatives, named strebluses C and D, were isolated from the EtOAc-soluble fraction of the stems of (Moraceae). Its absolute configuration was elucidated based on NMR spectroscopic data interpretation and optical rotation calculation. Streblus C possesses strong tyrosinase inhibitory activity with an IC value of 0.

Two new derivatives of 8-prenyl-5,7-dihydroxycoumarin from the stems of (S.Vidal) Corn.

From the EtOAc-soluble extract of the stems of (Moraceae), two new secondary metabolites named strebluses A () and B () were isolated. Their chemical structures have been concluded based on the chemical derivatisation and the spectroscopic interpretation. All compounds have been tested for their tyrosinase inhibitory activity.

A new 8,3'-neolignan from Lour.

The phytochemical investigation of the EtOAc-soluble fraction of the aerial parts of Lour. has been carried out to obtain seven compounds, including a new 8,3'-neolignan named solacanin A (). Their chemical structures were elucidated based on the spectroscopic data interpretation.

A new 7',9-epoxylignan from the stems of .

Bioactivity-guided isolation of the CHCl-soluble fraction of the stems of L. (Celastraceae) was carried out to obtain a new 7',9-epoxylignan () and three 7,9':7',9-diepoxylignans (-). The absolute configuration of was elucidated based on NMR and ECD spectroscopic data interpretation.

Diarylalkanoids as Potent Tyrosinase Inhibitors from the Stems of .

From a CHCl-soluble extract of the stems of (Anacardiaceae), two new diarylalkanoids, semedienone () and semetrienone (), were isolated. Their structures were elucidated based on NMR spectroscopic data interpretation. These compounds possess strong tyrosinase inhibitory activity with the IC values of 0.

A new lignan from the stems of Blume (Anacardiaceae).

From the EtOAc-soluble extract of the stems of , one new lignan, (+)-(8,8')-5'-methoxy-4,4'-di--methylsecoisolariciresinol (), together with five known compounds () were isolated. Their structures were elucidated on the basis of NMR spectroscopic interpretation. The absolute configuration of was determined based on the Cotton effects in the ECD spectrum.

Panduratins Q-Y, dimeric metabolites from Boesenbergia rotunda and their antiausterity activities against the PANC-1 human pancreatic cancer cell line.

A methanolic extract of the rhizomes of Boesenbergia rotunda showed potent preferential cytotoxicity against PANC-1 human pancreatic cancer cells under nutrient deficiency conditions with a PC value of 6.6 μg/mL. Bioactivity-guided phytochemical investigation of the rhizomes of B.

A new flavanone derivative from the rhizomes of .

From the methanolic extract of the rhizomes of , a new flavanone derivative named (2,7″)-8-(1-phenyl-2-carboxyethyl)pinocembrin () and four known flavonoids (-) were isolated. Its absolute configuration was concluded by NMR and MS spectroscopic analysis, together with comparison between experimental and calculated ECD data. In turn, compound exhibited strong cytotoxicity against the PANC-1 human pancreatic cancer cell line with a PC value of 6.

Decumbic anhydride from the stem barks of (Anacardiaceae).

From an EtOAc-soluble fraction of the stem barks of (Anacardiaceae), decumbic anhydride () and four known compounds - were isolated. Their chemical structures were elucidated based on the spectroscopic data interpretation. The GIAO-DFT calculation of C NMR chemical shifts was carried out to clarify the structure of .

Paratrimerin I, cytotoxic acridone alkaloid from the roots of .

Bioactivity-guided fractionation of the CHCl-soluble extract of the roots of was carried out to obtain a new acridone alkaloid, paratrimerin I. Its structure was elucidated based on NMR spectroscopic data interpretation. Paratrimerin I showed noteworthy cytotoxicity against the HepG2 human hepatocellular and MCF-7 human breast carcinoma cell lines, with the submicromolar IC values of 0.