Publications by authors named "Thng Shu Hui"
Introduction: As the population ages, the prevalence rate of behavioral and psychologic symptoms of dementia (BPSD) rises, and there appears to be an increasing need for pharmacologic treatment where nonpharmacologic treatment would not suffice. Most clinicians are well aware of the increased risks of cerebrovascular event and mortality from antipsychotic use in older adults with dementia. Nevertheless, mortality risks reported in various publications still vary considerably and lack consistency to allow direct comparison between individual drugs.
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- Identifying the right mammalian cell lines, particularly CHO cells, is essential for efficient production of monoclonal antibodies (mAbs).
- This study uses metabolomics to compare metabolite profiles of eight CHO cell clones with varying mAb production rates, finding significant differences that correlate to their productivity.
- Seven key metabolites were identified, linked to critical cellular processes, suggesting that high-producing cell lines maintain better redox status and energy regulation to enhance mAb production.