Efficient ZFN-Mediated Stop Codon Integration into the CCR5 Locus in Hematopoietic Stem Cells: A Possible Source for Intrabone Marrow Cell Transplantation.

We reported a simple genome editing approach that can generate human immunodeficiency virus-1 (HIV) coreceptor defective cells, which may be useful for latent viral eradication treatment. Samples of bone marrow leftover after diagnostic procedures and crude bone marrow from aviremic HIV patients were subjected to zinc finger nuclease-mediated stop codon insertion into chemokine receptor 5 (CCR5) loci. Locked nucleic acid-based polymerase chain reaction was used to estimate the amount of insertion in the expandable CD34 cells.

Cutaneous infections in immunocompromised patients in a tertiary hospital in Bangkok, Thailand: under-reported/under-recognized infection.

Introduction: is one of the non-tuberculous mycobacteria (NTM) that can cause cutaneous infection. As acid-fast staining cannot distinguish NTM from , and as skin culture for is not performed routinely, the diagnosis of infection in Thailand is rarely made.

Case Presentation: Between 2006 and 2009, five patients with infection were diagnosed in Ramathibodi Hospital, a tertiary care centre in Bangkok, Thailand.

Therapeutic effectiveness of a generic versus original meropenem in serious infections.

Background: Meropenem plays a significant role in the current antimicrobial treatment of serious infections. Recently, generic meropenems have become widely available in Thailand.

Objective: Compare the effectiveness and safety ofa generic meropenem (Mapenem) with the original meropenem (Meronem) in clinical practice.