Targeting FGFRs Using PD173074 as a Novel Therapeutic Strategy in Cholangiocarcinoma.

Cholangiocarcinoma (CCA) is an architecturally complex tumour with high heterogeneity. Discovery at later stages makes treatment challenging. However, the lack of early detection methodologies and the asymptomatic nature of CCA make early diagnosis more difficult.

Effect of Combining EGFR Tyrosine Kinase Inhibitors and Cytotoxic Agents on Cholangiocarcinoma Cells.

Purpose: The potential of members of the epidermal growth factor receptor (ErbB) family as drug targets in cholangiocarcinoma (CCA) has not been extensively addressed. Although phase III clinical trials showed no survival benefits of erlotinib in patients with advanced CCA, the outcome of the standard-of-care chemotherapy treatment for CCA, gemcitabine/cisplatin, is discouraging so we determined the effect of other ErbB receptor inhibitors alone or in conjunction with chemotherapy in CCA cells.

Materials And Methods: ErbB receptor expression was determined in CCA patient tissues by immunohistochemistry and digital-droplet polymerase chain reaction, and in primary cells and cell lines by immunoblot.

Immunohistochemistry of Cytokeratin 7, Cytokeratin 20 and Thyroid Transcription Factor-1 in Metastatic Carcinoma of Cervical Lymph Node Biopsy for Identification of Pulmonary Origin in Rajavithi Hospital.

Background: One of the most powerful tools used in “the team approach in modern medicine” is immunohistochemistry, a minimally invasive investigative technique which is helpful in many respects, such as in suggesting or defining the primary site of metastatic malignant neoplasms. The panel of Cytokeratin7 (CK7), Cytokeratin20 (CK20) and Thyroid Transcription Factor-1 (TTF-1) is one of the most frequently used, and this study examined expressions of this panel in Rajavithi Hospital in order to assess their significance.

Objective: To study the expression of CK7, CK20 and TTF-1 in metastatic carcinoma in neck node biopsy found in the Rajavithi Hospital database, and to assess their effectiveness in identifying pulmonary origin.

Langerhans' cell histiocytosis (LCH) in adolescence presented with central diabetes insipidus: a case report.

A 19-year-old Thai man presented with symptoms of central diabetes insipidus, exopthalmos and multiple ostolytic lesions of the cranial vault. Skin biopsy showed strongly positive CD 1a and S100. Electron microscopy showed rod shape and pentalaminar granules called "Birbeck" granules, a diagnosis compatible with Langerhans' cell histiocytosis (LCHs) or histiocytosis X.