Evaluation of polyherbal synergy against diabetes: analysis.

Aims: To evaluate the anti-diabetic properties of a polyherbal formulation consisting of , , and through assays, and investigate its synergistic effects on glucose metabolism, lipid metabolism, and insulin function.

Materials And Methods: The polyherbal extract was prepared using methanol, water, and methanol-water as solvents. antioxidant (DPPH, Phosphomolybdenum) and anti-diabetic (α-amylase, α-glucosidase inhibition, yeast glucose uptake, and inhibitory glucose diffusion) assays were conducted.

Evaluation of the Liver and Pancreatic Functions in Patients with Alcohol-Related Sialadenosis - A Case Control Study.

Background: Sialadenosis or sialosis is the asymptomatic symmetric parotid enlargement without inflammation or neoplasia, seen in persons 30-69 years old, often related to chronic alcohol use, endocrine disorders, and obesity.

Materials And Methods: This was a case-control study done at Rajah Muthiah Dental College and Hospital from September 2013 to July 2014, comprising 15 patients with alcoholic sialadenosis (Group A) and comparing them with 15 alcoholic patients without sialadenosis (Group B). Parameters monitored for liver and pancreatic functions were their serum levels of AST, ALT, GGT, ALP, amylase, and lipase.

Pre-clinical evaluation of Tc-labeled chalcone derivative for amyloid-β imaging post-head trauma.

Aβ plaque formation is one of the preliminary pathologic events that occur post traumatic brain injury (TBI) which is also among the most noteworthy hallmarks of AD. Their pre symptomatic detection is therefore vital for better disease management. Chalcone-picolinic acid chelator derivative, 6-({[(6-carboxypyridin-2-yl)methyl](2-{4-[(2E)-3-[4-(dimethyl amino)phenyl]prop-2-enoyl]phenoxy}ethyl)amino}methyl)pyridine-2-carboxylic acid, Py-chal was synthesized to selectively identify amyloid plaques formed post head trauma using SPECT imaging by stable complexation to Tc with > 97% efficiency without compromising amyloid specificity.

Assessment of sex and sexual dimorphism in children from Tamilnadu, India through odontometrics in primary dentition - a cross sectional study with discriminant function analysis.

One of the crucial steps in the process of identification of human remains is sex determination of an unknown individual. Sex can be determined using the human skeleton, especially by examining the pelvis and skull. Odontometric analysis and assessment of sexual dimorphism of the human dentition has been less investigated, especially in primary dentition.

GC-MS based metabolite profiling, antioxidant and antiurolithiatic properties of apple cider vinegar.

Aim: To perform analysis of antioxidant and antiurolithiasis to carry out GC-MS-based metabolite profile.

Materials & Methods: The effect of apple cider vinegar (ACV) , antioxidant and GC-MS analysis was evaluated. The antioxidant studies were performed.

Phytochemical and biological review of Linn.

India has one of the most expanded plant-origin medical traditions in the world. Researchers have evaluated molecules obtained from plants to treat a variety of ailments. Literature review shows that fundamental parts of the plant are used to treat different diseases.

Bio-Evaluation of Tc-Labeled Homodimeric Chalcone Derivative as Amyloid-β-Targeting Probe.

Chalcone derivatives have been successfully utilized for a range of biological applications and can cross the blood-brain barrier easily. β-amyloid-specific bis-chalcone derivative, 6,9-bis(carboxymethyl)-14-(4-[(E)-3-(4-(dimethylamino)phenyl)acryloyl]phenoxy)-3-(2-[(2-(4-[(E)-3-(4-(dimethylamino)phenyl)acryloyl]phenoxy)ethyl)amino]-2-oxoethyl)-11-oxo-3,6,9,12-tetraazatetradecanoic acid, DT(Ch), was analyzed using molecular modeling to explain the binding modes of the ligand with amyloid fibril and monomer followed by Tc-complexation in 95% yield and 98.7% efficiency.

Fabrication of AgNi Nano-alloy-Decorated ZnO Nanocomposites as an Efficient and Novel Hybrid Catalyst to Degrade Noxious Organic Pollutants.

Contamination through industrial effluents is a major threat to the environment. Degradation of organic pollutants remains a major challenge, and semiconductor-based catalysis is reported to be a viable solution. Recently, AgNi bimetallic alloy nanoparticles attracted great attention with superior properties.

Receptor mapping using methoxy phenyl piperazine derivative: Preclinical PET imaging.

This study aimed at assessing 2-methoxyphenyl piperazine derivative for its binding specificity and suitability in mapping metabotropic glutamate receptor subtype 1, which is implicated in several neuropsychiatric disorders. N-(2-(4-(2-Methoxyphenyl)piperazin-1-yl)ethyl)-N-methylpyridin-2-amine was synthesised and evaluated for brain imaging subsequent to radiolabelling with [C] radioisotope via methylation process in 98.9% purity and 52 ± 6% yield (decay corrected).

Efficient Charge Transfer in Heterostructures of CdS/NaTaO with Improved Visible-Light-Driven Photocatalytic Activity.

Photocatalyst NaTaO with a cube-shaped morphology and an average particle size of 100 nm was synthesized using an effortless hydrothermal method. The composite heterostructures of CdS/NaTaO with variable concentrations of CdS were fabricated after the surface functionalization of bare NaTaO using 3-mercaptopropionic acid. As-synthesized photocatalysts were characterized using powder X-ray diffraction analysis, Raman spectroscopy, field-emission scanning and transmission electron microscopies with energy-dispersive X-ray spectroscopy furnished with elemental mapping, multipoint Brunauer-Emmett-Teller (BET), and UV-vis diffuse reflectance spectroscopy.

Synthesis and antimycobacterial activity of 1-(β-d-Ribofuranosyl)-4-coumarinyloxymethyl- / -coumarinyl-1,2,3-triazole.

A series of β-d-ribofuranosyl coumarinyl-1,2,3-triazoles have been synthesized by Cu-catalyzed cycloaddition reaction between azidosugar and 7-O-/7-alkynylated coumarins in 62-70% overall yields. The in vitro antimycobacterial activity evaluation of the synthesized triazolo-conjugates against Mycobacterium tuberculosis revealed that compounds were bactericidal in nature and some of them were found to be more active than one of the first line antimycobacterial drug ethambutol against sensitive reference strain H37Rv, and 7 to 420 times more active than all four first line antimycobacterial drugs (isoniazid, rifampicin, ethambutol and streptomycin) against multidrug resistant clinical isolate 591. Study of in silico pharmacokinetic profile indicated the drug like characters for the test molecules.

PrFeCrO: A Type I Multiferroic.

We synthesized double perovskite PrFeCrO by solid-state method. Analysis of its X-ray powder diffraction shows that the compound crystallizes in a centrosymmetric structure with space group Pbnm. Our X-ray photoelectron spectroscopy (XPS) studies show that all the cations are present in +3 oxidation state.

Visible-Light-Driven Photoelectrochemical and Photocatalytic Performance of NaNbO3 /Ag2 S Core-Shell Heterostructures.

Herein, we report the fabrication of visible-light-active NaNbO3 /Ag2 S staggered-gap core-shell semiconductor heterostructures with excellent photoelectrochemical activity toward water splitting, and the degradation of a model pollutant (methylene blue) was also monitored. The heterostructures show a pronounced photocurrent density of approximately 2.44 mA cm(-2) at 0.

Metal based imaging probes of DO3A-Act-Met for LAT1 mediated methionine specific tumors: synthesis and preclinical evaluation.

Purpose: Tumor cells are known to have an elevated requirement for methionine due to increased protein synthesis and trans-methylation reactions. A methionine based macrocyclic tumor imaging system, DO3A-Act-Met, has been designed to provide a novel platform for tumor imaging via modalities, PET/MRI using metal ions, (68)Ga and (157)Gd.

Methods: Synthesis of DO3A-Act-Met was confirmed through NMR and mass spectrometric techniques.

Achieving enhanced visible-light-driven photocatalysis using type-II NaNbO3/CdS core/shell heterostructures.

Expanding the light-harvesting range and suppressing the quick recombination of photogenerated charge carriers are of paramount significance in the field of photocatalysis. One possible approach to achieve wide absorption range is to synthesize type-II core/shell heterostructures. In addition, this system also shows great promise for fast separation of charge carriers and low charge recombination rate.

Design and synthesis of calcium responsive magnetic resonance imaging agent: Its relaxation and luminescence studies.

Calcium concentration modulation both inside and outside cell is of considerable interest for nervous system function in normal and pathological conditions. MRI has potential for very high spatial resolution at molecular/cellular level. Design, synthesis and evaluation of Gd-DO3A-AME-NPHE, a calcium responsive MRI contrast agent is presented.

Facile synthesis of non-ionic dimeric molecular resonance imaging contrast agent: its relaxation and luminescence studies.

A bis-polyazamacrocycle, 10'-bis(acetamido)ethane-bis[1,4,7-tri(carboxymethane)-1,4,7,10-tetraazacyclododecane] (DO3A-AME-DO3A) was synthesized for application in magnetic resonance imaging. The efficacy of DO3A-AME-DO3A as non ionic magnetic contrast agent was tested by performing relaxometric studies on its gadolinium complex. The longitudinal relaxivity, r(1) and transverse relaxivity, r(2) values were found to be 5.

Preclinical evaluation of DO3P-AME-DO3P: a polyazamacrocyclic methylene phosphonate for diagnosis and therapy of skeletal metastases.

A phosphonate derivative 10'-bis(acetamido)-ethane-bis[1,4,7-tri(methylene phosphonic acid)-1,4,7,10-tetraazacyclododecane] (DO3P-AME-DO3P), was synthesized with 90% yield in high purity. It was labeled with (99m)Tc in 97.5% efficiency and specific activity of 112-250 MBq/μmol.

Use of gentamicin impregnated POP discs for antibiotic pouch dressing.

Antibiotic pouch technique is commonly used due to the high local antibiotic concentration and moist environment for wound healing. We used locally made gentamicin impregnated Plaster of Paris discs in treating wounds with exposed deep structures like tendons and bones. Out of 22 patients treated with this method, 19 completed treatment.

Bone transport in the management of fractures of the tibia.

A review was carried out in 21 cases of bone transport in the tibia done between May 1995 and December 1997. These were done for the treatment of compound (Grade IIIB) fractures with extensive bone and soft tissue loss and in infective non-unions of the tibia using the Ilizarov technique and ring fixator. In 5 cases, 2 or 3 additional procedures were needed such as tendo achilles (TA) lengthening, bone grafting, revision of construct or revision of scar at the docking site.