Publications by authors named "Thiruchelvam N"

Objectives: Do weekly prophylactic saline or acidic catheter washouts in addition to standard long-term catheter (LTC) care improve the outcomes of adults with LTC compared with standard LTC care only.

Design: Three-arm superiority open-label randomised controlled trial.

Setting: UK community-based study.

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Background: Clean intermittent self-catheterisation (CISC) with conventional eyelet catheters (CECs) is associated with urine flow-stops, which require the catheter to be repositioned so flow can resume. Flow-stops often occur because bladder mucosa is sucked into the eyelets.

Aims: This investigation aimed to compare the bladder-emptying performance of the micro-hole zone catheter (MHZC) with the CEC.

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Article Synopsis
  • - The SATURN registry, a European multicenter study, aims to evaluate the effectiveness of surgical devices for treating male stress urinary incontinence, focusing on cure rates during a 10-year follow-up, with 1-year results currently reported.
  • - The study involved 1,046 male patients, primarily post-radical prostatectomy, using various implants like AMS800 and Advance, and showed varying self-reported continence rates—ranging from 11% to 76% depending on the device, with 32% of patients still experiencing incontinence after one year.
  • - Patient-reported outcomes indicated improvements in quality of life, but a notable percentage of patients required revisions of their devices, suggesting complications remained a concern
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Aims: To confirm the improved performance of the micro-hole zone catheter (MHZC) compared to a conventional eyelet catheter (CEC) in male users of clean intermittent catheterizations (CICs).

Methods: Male self-catheterizing subjects, who used hydrophilic sleeved soft/flexible CIC as the only bladder emptying method, were enrolled into a multi-center, randomized, cross-over study performed across six European sites. Subjects tested the MHZC, featuring a drainage zone with 120 micro-holes and a CEC with two eyelets.

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Objective: To examine the safety and efficacy of prostatic urethral lift (PUL) in acute urinary retention (AUR) patients within a controlled (PULSAR) and real-world setting (Real-World Retrospective study).

Materials And Methods: PULSAR was a 12-month prospective study of PUL in AUR patients ( = 51) performed at six centres in the United Kingdom; enrolled BPH patients aged ≥50 years, with prostate volume of ≤100 cc. AUR was defined as being catheter dependent with at least one prior failed trial without catheter (TWOC) while on an alpha-blocker.

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Article Synopsis
  • - Surgery for male incontinence with artificial urinary sphincters and slings (SATURN) is an observational study aimed at gathering data on male stress urinary incontinence surgeries across various European centers.
  • - The registry will assess both short- and long-term outcomes of these surgeries, focusing on their effectiveness and how they affect patients' quality of life.
  • - By collecting this prospective data, the study aims to improve understanding and treatment strategies for male urinary incontinence.
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Background: Evidence shows that intermittent catheterisation (IC) for bladder emptying is linked to urinary tract infections (UTIs) and poor quality of life (QoL).

Aim: To investigate the association between UTI risk factors and QoL and patient-reported UTIs respectively.

Methods: A survey was distributed to IC users from 13 countries.

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Minimally invasive pancreatoduodenectomy (MIS PD) is a well reported technique with several advantages over conventional open pancreatoduodenectomy. In comparison to distal pancreatectomy, the adoption of MIS PD has been slow due to the technical challenges involved, particularly in the reconstruction phase of the pancreatojejunostomy (PJ) anastomosis. Hence, we introduce a low-cost model for PJ anastomosis simulation in MIS PD.

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Robotic surgery has revolutionized the field of minimally invasive oncologic surgery. The Da Vinci Xi platform is a significant upgrade from older Da Vinci platforms facilitating multiquadrant and multi-visceral resection. We review the current technical factors and outcomes in robotic surgery for simultaneous resection of colon and synchronous liver metastases (CLRM) and provide future perspective on technical considerations for combined resection.

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Objective: To estimate the cost-effectiveness of single-use hydrophilic-coated intermittent catheters (HCICs) versus single-use uncoated intermittent catheters (UICs) for urinary catheterization.

Methods: The evaluation took a UK national health service (NHS) perspective. The population of interest were people using intermittent catheters, with either a spinal cord injury or multiple sclerosis.

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Background: Recommendations for the management of pain related to pelvic mesh implants are still under development. One limitation that has impeded progress in this area is that mesh-related pain has not been consistently defined or measured. Here, we reviewed the ways in which pain associated with pelvic mesh implants has been measured, and mapped the ways in which these existing measures capture the construct.

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Background: Various washout policies are widely used in adults living with long-term catheters (LTC). There is currently insufficient evidence on the benefits and potential harms of prophylactic LTC washout policies in the prevention of blockages and other LTC-related adverse events, such as urinary tract infections. CATHETER II tests the hypothesis that weekly prophylactic LTC washouts (normal saline or citric acid) in addition to standard LTC care reduce the incidence of catheter blockage requiring intervention compared to standard LTC care only in adults living with LTC.

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Background: Women with stress urinary incontinence (SUI) experience urine leakage with physical activity. Currently, the interventional treatments for SUI are surgical, or endoscopic bulking injection(s). However, these procedures are not always successful, and symptoms can persist or come back after treatment, categorised as recurrent SUI.

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This study assessed the feasibility of dynamic transperineal ultrasound (TPUS) pre/post-radical prostatectomy (RP). Ninety-eight patients were scanned pre-operatively and at four time-points post-operatively. TPUS was performed in 98 patients using an abdominal transducer at rest, during pelvic floor contraction (PFC) and Valsalva (VS) maneuver in supine and standing positions.

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Background: Daily, low-dose antibiotic prophylaxis is the current standard care for women with recurrent urinary tract infection. Emerging antimicrobial resistance is a global health concern, prompting research interest in non-antibiotic agents such as methenamine hippurate, but comparative data on their efficacy and safety are lacking.

Objective: To assess the clinical effectiveness and cost-effectiveness of methenamine hippurate (Hiprex; Mylan NV, Canonsburg, PA, USA) compared with current standard care (antibiotic prophylaxis) for recurrent urinary tract infection prevention in adult women.

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Objective: To test and compare the efficacy of methenamine hippurate for prevention of recurrent urinary tract infections with the current standard prophylaxis of daily low dose antibiotics.

Design: Multicentre, open label, randomised, non-inferiority trial.

Setting: Eight centres in the UK, recruiting from June 2016 to June 2018.

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Purpose Of Review: A continent vesicostomy represents a useful alternative for adult patients with impaired bladder emptying who are unable to perform clean intermittent (self-) catheterization through the urethra. In a pediatric setting, there exists a vast experience in these procedures. But experience with continent catheterizable vesicostomies is less abundant in adult patients.

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As laparoscopic approach becomes increasingly routine for liver resections, several centers have also adopted the robotic approach for its many purported benefits of magnified steady views, intuitive instrument articulation, and tremor filtration amongst others. In this article we highlight the technical considerations specific to robotic-assisted laparoscopic liver resections for the da Vinci robotic Xi Surgical System.

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Prostate cancer is the second most common male cancer, and radical prostatectomy is a highly effective treatment for intermediate and high-risk disease. However, post-prostatectomy urinary incontinence remains a major functional side-effect in patients undergoing radical prostatectomy. Despite recent improvements in preoperative imaging quality and surgical techniques, it remains challenging to predict or prevent occurrence of this complication.

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Article Synopsis
  • Injuries to the bladder and ureter are rare and often need quick urological care.
  • Urologists may not have extensive experience in handling these issues due to their uncommon nature and possible lack of access to specialized surgical expertise.
  • The FNUU Section of BAUS is creating a consensus statement to offer guidance and establish a management pathway to support clinicians in treating these injuries effectively.
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Article Synopsis
  • The document aims to provide expert advice on managing long-term catheter complications, created by the Female, Neurological and Urodynamic Urology (FNUU) section of BAUS, in collaboration with BAUN.
  • A comprehensive literature review and expert feedback were utilized to inform the guidance, with reviews from various committees and presentations at a key urology meeting for broader input.
  • Key findings include complications from indwelling catheters, such as urinary tract infections and bladder issues, along with a set of recommendations and troubleshooting strategies for effective management.
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Objectives: To report the British Association of Urological Surgeon's (BAUS) guidance on the assessment and management of female voiding dysfunction.

Methods: A contemporary literature search was conducted to identify the evidence base. The BAUS Section of Female, Neurological and Urodynamic Urology (FNUU) Executive Committee formed a guideline development group to draw up and review the recommendations.

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