Publications by authors named "Thiruchelvam K"
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Introduction: Acute myocardial infarction (AMI) poses a significant global health burden, warranting meticulous management strategies, particularly in patients with concurrent anemia. Blood transfusion strategies play a pivotal role in optimizing oxygen delivery while minimizing transfusion-related risks. Two contrasting approaches, liberal and restrictive transfusion strategies, have emerged, yet their comparative effectiveness remains uncertain due to conflicting evidence.
View Article and Find Full Text PDFThe use of nonsteroidal anti-inflammatory drugs (NSAIDs), particularly diclofenac, during the COVID-19 pandemic has raised concerns due to its potential to worsen disease progression. This commentary evaluates key risks associated with diclofenac and highlights the critical role of pharmacists in mitigating adverse outcomes through careful medication management and patient education. Diclofenac poses unique risks due to its ability to generate reactive oxygen species (ROS), leading to oxidative stress and mitochondrial dysfunction.
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- Vitamin D is being investigated for its potential to reduce mortality in COVID-19 patients, based on its known role in bone health and immunomodulation.
- A systematic review and meta-analysis included 19 randomized controlled trials with a total of 2,495 participants, showing that vitamin D supplementation significantly lowers all-cause mortality (pooled OR 0.72) and even more so in severe COVID-19 cases (pooled OR 0.57).
- The study suggests that vitamin D could be a beneficial adjunct treatment for COVID-19 patients, but more extensive research is needed to confirm the findings and identify the best dosing strategies.
Background: Psoriasis is a chronic erythematous inflammatory skin disorder. The major challenge with psoriasis is delayed diagnosis, resulting in delayed treatment initiation and reduced quality of life (QoL).
Objective: This patient perspective study aimed to explore the emotional and psychosocial burdens faced by patients with psoriasis in Malaysia and their attitudes toward current psoriasis treatment.
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- * Nine trials were analyzed, revealing a significant reduction in overall mortality odds when IVIG was used, but results varied depending on the quality of the trials and patient severity.
- * The researchers caution against drawing strong conclusions about IVIG's effectiveness, highlighting the need for larger, better-designed studies for more reliable results, especially in severe COVID-19 cases.
This article explores the potential link between COVID-19 and parkinsonism, synthesizing existing evidence and recent research findings. It highlights limitations in current understanding, emphasizes the direct impact of the virus on dopamine neurons, and calls for continued research to elucidate long-term neurological implications and optimize patient care strategies.
View Article and Find Full Text PDFObjectives: To determine risks associated with uricosurics in COVID-19 patients.
Methods: A systematic review and meta-analysis was conducted by systematically searching electronic databases.
Key Findings: The pooled analysis of the included trials revealed that the use of uricosurics was not associated with the risk of mortality (pooled odds ratio [OR] = 1.