hypoxia modulating nano-catalase for amplifying DNA damage in radiation resistive colon tumors.

Radiation therapy (RT) is a mainstream clinical approach in cancer treatment. However, the therapeutic efficacy of RT is greatly hindered by the presence of excessive hydrogen peroxide (HO) in the hypoxic region of the solid tumor, thus leading to tumor recurrence and metastasis. Herein, a thioketal-linked amphiphilic nano-assembly (MTS) loaded with hydrophobic manganese oxide (HMO) nanoparticles (MTS@HMO) is examined as a promising multi-purpose reactive oxygen species (ROS)-catalytic nanozyme for transforming an RT-resistant hypoxic tumor microenvironment (TME) into an RT-susceptible one by scavenging ROS in the hypoxic core of the solid tumor.

Enhancing the remarkable adsorption of Pb in a series of sulfonic-functionalized Zr-based MOFs: a combined theoretical and experimental study for elucidating the adsorption mechanism.

A series of Zr-based metal-organic frameworks was prepared the solvothermal route using sulfonic-rich linkers for the efficient capture of Pb ions from aqueous medium. The factors affecting adsorption such as the solution pH, adsorbent dosage, contact time, adsorption isotherms, and mechanism were studied. Consequently, the maximum adsorption capacity of Pb on the acidified VNU-23 was determined to be 617.

A new approach for ultra-high adsorption of cationic methylene blue in a Zr-sulfonic-based metal-organic framework.

A series of Zr-sulfonic-based metal-organic frameworks have been synthesized by the solvothermal method, namely VNU-17 and VNU-23. Particularly, VNU-17 and VNU-23 adopt the sulfonate group (SO ) moieties densely packed within their structure, which can efficiently uptake MB from wastewater. The maximum adsorption capacity for MB onto VNU-23 is up to 1992 mg g at pH = 7, which is more than five times that of activated carbon and possesses the highest value among all the reported MOF materials.