Co-occurrence of Anti-GAD65 Syndrome, Type 1 Diabetes Mellitus, and Focal Seizures With Impaired Awareness.

Glutamic acid decarboxylase (GAD) is an intracellular enzyme found in the presynaptic end of nerve terminals that functions to synthesize ​​gamma-aminobutyric acid (GABA) via decarboxylation. Autoantibodies to the GAD65 isoform have been found in high levels in neurological disorders including stiff person syndrome (SPS), autoimmune encephalitis, and refractory epilepsy. Low levels of anti-GAD65 have also been noted in type 1 diabetes mellitus.

Diet and cancer--an international study.

The notion that nutritional intake and cancer are interrelated is an old one and the strength of this relationship is dependent upon the proportion of underdeveloped and developed countries among the total number of countries investigated. The protein, fat and caloric intake is lower in underdeveloped versus developed countries. The positive association of intestine, rectum and breast cancers with food intake is biologically logical whereas the positive association of lymphatic, haemopoietic and myeloid leukaemias and skin cancer make no biological sense suggesting that strength of association by itself does not imply causality.

Gastrointestinal cancer mortality in New Jersey counties, and the relationship with environmental variables.

The State of New Jersey (NJ) USA has been thought to have an unusually high cancer mortality rate; this assumption has been based on 1950-1969 mortality data for its 21 counties. This paper presents an analysis of gastrointestinal (GI) cancer mortality rates in New Jersey counties during 1968-1977, a comparison with the 1950-1969 rates, and associations between current GI cancer mortality rates and selected environmental variables. Age-adjusted mortality rates for GI cancers were calculated for the 21 NJ counties during the period 1968-1977, and were compared with the period 1950-1969, with the Surveillance, Epidemiology and End Results (SEER) survey and with cancer mortality in the US, 1973-1977.

Emetine-induced cardiomyopathy in rabbits.

A correlative electrocardiographic and ultrastructural study of myocardium in rabbits, administered 1 mg/kg of emetine hydrochloride intramuscularly for 5 successive days of a week over 2 to 4 week period, was conducted. The study revealed electrocardiographic changes and a spectrum of ultrastructural lesions involving myocardial cells and interstitial neural elements. The severity of these lesions was related to the cumulative dose of the drug.

Life time occupation, smoking, caffeine, saccharine, hair dyes and bladder carcinogenesis.

A case-control study of bladder cancer in two northern counties of New Jersey was conducted to investigate a tumour that has been considered to be strongly associated with industrial and environmental exposures. The study population included 75 bladder cancer cases and 142 controls. Cases and controls were matched for race, sex, age, place of birth and place of residence.

Cancer among blacks in Newark, New Jersey, 1970-1976: a national and international comparison.

Newark black men had age-adjusted cancer rates comparable to those of Washington, D. C., but lower than the other three American city blacks.

Cancer mortality in a pigment plant utilizing lead and zinc chromates.

Several studies of workers exposed to various forms of chromium compounds have suggested an increased incidence of respiratory cancers. Lead and zinc chromates were among the chromium compounds implicated. The Department of Preventive Medicine and Community Health of the New Jersey Medical School undertook a detailed mortality study of a pigment plant in Newark which utilized both of these compounds.

Carcinoma of the cervix in Newark, New Jersey, 1970-76. A very low in situ: invasive ratio.

Both blacks and whites in Newark had significantly lowered incidences of in situ cervical cancer as compared to the Third National Cancer Survey (TNCS) population. In contrast, Newark blacks' invasive cancer rates were higher than those found in any individual geographic area surveyed in TNCS except for Minneapolis as compared to Newark whites, who had lower rates than all individual TNCS areas except Colorado and San Francisco. Newark blacks had a relative risk of 4.

Signification of high density and total cholesterol and triglycerides in acute myocardial infarction -- a case-control study.

This case-control study of acute myocardial infarction showed no statistical significant difference between the mean total cholesterol levels (5.45 vs. 5.

Cancer incidence and mortality in Newark, N. J. 1970-1974: a national comparison.

New Jersey has acquired the invidious label "Cancer Alley U. S. A.

Control of hepatitis B infection. The role of surveillance and an isolation hemodialysis center.

A 3 1/4-year study assessed intervention approaches for hemodialysis-associated hepatitis. A 12-month retrospective study was followed by one year of prospective surveillance (during which attention to hygienic techniques was encouraged) and then by a 15-month period during which antigen-positive cases were transferred from study centers to an isolation hemodialysis center (IHL). The incidence of hepatitis B infection (HBI) fell 35.

Composition of tobaccos from countries with high and low incidences of lung cancer. I. Selenium, polonium-210, Alternaria, tar, and nicotine.

Tobaccos from countries with high and low incidences of lung cancer were analyzed. Tobacco concentrations of polonium-210 were similar in cigarettes from high- and low-incidence countries, as were levels of cigarette smoke tar and nicotine. Tobaccos from low-incidence countries had significantly lower Alternaria spore counts.

Comparative evaluation of two lots of Wister RA 27/3 rubella virus vaccine in young children.

Two lots [RS 3/2 and RU 4/17] of Wistar RA 27/3 Rubella virus vaccine with about 50-fold difference in concentration of virus per dose were administered to 203 children of less than 5 years of age with negative immunization or natural rubella history and followed for 6-7 weeks. Complete information was collected on 194 children. Eighteen of the 19 children with positive prevaccination hemagglutination inhibition [HAI] titers responded with 4-fold or higher rise following vaccination with no side reactions.

Geographic variations in coronary heart disease. A perspective on risk factors and prevention.

Mankind's greatest epidemic: heart disease--ischemic heart disease or coronary heart disease (CHD)--has reached epidemic proportions striking more and more at younger subjects. It will result in coming years, in the greatest epidemic mankind has faced unless we are able to reverse the trend by concentrated research into its causes and prevention. Under the auspices of the World Health Organization the [executive] board expressed a wish that countries most affected by cardiovascular diseases increase their efforts, both to set up efficient services for control and to carry out more extensive research programs (20).

Infant mortality in Newark, New Jersey. A study of sociodemographic and medical factors.

Newark, a metropolitan industrial town, experienced the highest infant mortality of any major city in the United States in the 1960s and early 1970s. Between 1970 and 1973, however, infant mortality among non-whites in this city declined strikingly. This decline could not be directly related to declines (a) in birth rates, (b) in the proportions of babies of low birth weight, (c) in the proportions of babies born to mothers in unfavorable age groups, (d) in the general fertility rates, or (e) in the illegitimacy rates.

Intake of magnesium and toxicity of lead: an experimental model.

Groups of ten male Wistar rats were fed 100 mg lead/kg body wt . day, or 100 mg lead plus 250 mg Mg . kg body wt .

Plasma concentrations of calcium, chromium, copper, iron, magnesium, and zinc in maternal and cord blood and their relationship to low birth weight.

A study of the relationship between low birth weight and concentrations of six metals in maternal and cord plasma was conducted. Maternal and cord blood were collected at delivery. Cases and controls were matched for maternal age (+/- 3 yr), race, parity, socioeconomic status, and smoking habits and the sex of the neonate.