Publications by authors named "Thimappa Ramachandrappa Lakshmeesha"

This study emphasized on the synthesis of zinc oxide nanoparticles (ZnO NPs) in an environmentally friendly manner from the extract of Catharanthus roseus leaves and its antibacterial assessment against the pneumonia-causing pathogen Klebsiella pneumoniae. This simple and convenient phytosynthesis approach is found to be beneficial over conventional methods, wherein plants serve as excellent reducing, capping, and stabilizing agents that enables the formation of ZnO NPs without the use of harmful chemicals. The formation of ZnO NPs was confirmed through several characterization techniques such as UV-visible spectroscopy, XRD, FT-IR, SEM, HR-TEM, and EDX.

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Cerium oxide nanoparticles (CeONPs) have a broad scale of applications in the biomedical field due to their excellent physicochemical and catalytic properties. The present study aims to synthesize the CeONPs from () leaf extract, which has been used in Indian traditional medicine for its neuroprotective properties. The CeONPs were characterized by ultraviolet-visible, X-ray diffraction, Fourier transform infrared, Raman spectroscopy, scanning electron microscopy- energy dispersive X-ray spectroscopy, and high-resolution transmission electron microscopy.

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Article Synopsis
  • * A study isolated a specific microorganism from soil to synthesize zinc oxide nanoparticles (ZnO NPs), which were tested against human pathogens.
  • * The results showed that ZnO NPs effectively inhibited bacterial growth and prevented biofilm formation, suggesting their potential use in treating drug-resistant infections.
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Purpose: 4-Hydroxyisophthalic acid (4-HIA) is a bioactive compound present in the roots of , which has attracted considerable attention in attenuating oxidative stress-related neurodegenerative diseases. However, its efficacy is limited because of its low solubility and bioavailability. Therefore, the present study aimed to encapsulate 4-HIA using biocompatible copolymer polylactide-co-glycolide (PLGA) and evaluate its antioxidant and neuroprotective potential.

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Article Synopsis
  • The study developed a method using endophytic fungal extracts to synthesize zinc oxide nanoparticles (ZnO NPs) and assessed their antimicrobial and anticancer potential.
  • Various characterization techniques confirmed that the synthesized ZnO NPs were pure, mostly hexagonal, and ranged from 34-55 nm in size, demonstrating effective antibacterial and antifungal properties.
  • The ZnO NPs showed significant internalization in cancer cells without damaging cell morphology, exhibiting notable anticancer effects at a concentration of 1 μg/mL.
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The Plant Growth Promoting Fungi (PGPF) is used as a source of biofertilizers due to their production of secondary metabolites and beneficial effects on plants. The present work is focused on the co-cultivation of spp. ( (PGT4), (PGT5) and (PGT13)) and the production of secondary metabolites from mono and co-culture and mycosynthesis of zinc oxide nanoparticles (ZnO NPs), which were characterized by a UV visible spectrophotometer, Powder X-ray Diffraction (PXRD), Fourier Transform Infrared Spectroscopy (FTIR) and Scanning Electron Microscopy (SEM) with Energy Dispersive Spectroscopy (EDAX) and Transmission Electron Microscope (TEM) and Selected Area (Electron) Diffraction (SAED) patterns.

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plant extract mediated propellant chemistry route was used for the green synthesis of zinc oxide nanoparticles. Prepared samples were confirmed for their nano regime using advanced characterization techniques such as powder X-ray diffraction and microscopic techniques such as scanning electron microscopy and transmission electron microscopy. The energy band gap of the green synthesized zinc oxide (ZnO)-nanoparticles (NPs) were found between 3.

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The development of advanced glycation end-products (AGEs) inhibitors is considered to have therapeutic potential in diabetic complications inhibiting the loss of the biomolecular function. In the present study, zinc oxide nanoparticles (ZnO-NPs) were synthesized from aqueous leaf extract of and were characterized by various techniques such as ultraviolet (UV)-Vis spectroscopy, Powder X-Ray Diffraction (PXRD), Fourier Transform Infrared Spectroscopy (FT-IR), Scanning electron microscopy (SEM), and energy dispersive spectroscopy (EDS). Further, the inhibition of AGEs formation after exposure to ZnO-NPs was investigated by in-vitro, in-vivo, and molecular docking studies.

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is a leading plant pathogen that causes Fusarium head blight, stalk rot, and Gibberella ear rot diseases in cereals and posing the immense threat to the microbiological safety of the food. Herein, we report the green synthesis of zinc oxide nanoparticles from (SaZnO NPs) flower bud extract by combustion method and investigated their application for controlling of growth and mycotoxins of . Formation of SaZnO NPs was confirmed by spectroscopic methods.

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