Publications by authors named "Thilo Kolb"
Article Synopsis
- Vaccination is crucial for kidney transplant recipients (KTRs) against SARS-CoV-2, but their immune response is often weaker than that of healthy individuals.
- The study analyzed the T-cell response in 148 KTRs, finding lower spike-specific T cell frequencies compared to controls, but a positive association was seen with spike-specific antibodies and certain vaccination strategies.
- KTRs who contracted SARS-CoV-2 post-vaccination exhibited significantly enhanced T-cell responses, indicating that hybrid immunity (from both vaccination and infection) provides stronger protection.
Article Synopsis
- A study examined how modifying vaccination strategies, specifically by reducing mycophenolate mofetil (MMF) doses, can enhance the immune response in kidney transplant recipients (KTRs) post-SARS-CoV-2 vaccination.
- Out of 174 previously seronegative KTRs, 32% became seropositive after a third vaccination, but only three developed neutralizing antibodies against the omicron variant.
- The findings suggest that a reduction of MMF by at least 33% prior to vaccination can significantly improve seroconversion rates in KTRs, potentially improving the effectiveness of the vaccine.
Background: Patients with kidney failure on dialysis or after renal transplantation have a high risk for severe COVID-19 infection, and vaccination against SARS-CoV-2 is the only expedient prophylaxis. Generally, immune responses are attenuated in patients with kidney failure, however, systematic analyses of immune responses to SARS-CoV-2 vaccination in patients on dialysis and in kidney transplant recipients (KTRs) are still needed.
Methods: In this prospective, multicentric cohort study, antibody responses to COVID-19 mRNA vaccines (BNT162b2 [BioNTech/Pfizer] or mRNA-1273 [Moderna]) were measured in 32 patients on dialysis and in 28 KTRs.
Patients with primary aldosteronism (PA) are more susceptible to cardiovascular disease and mortality than patients with primary hypertension. This is mostly attributed to excess production of aldosterone and its effects on the development of vascular injury. A novel functional test (T) measures serum calcification propensity.
View Article and Find Full Text PDFKidney transplant recipients (KTRs) are extremely vulnerable to SARS-CoV-2 infection and show an impaired immune response to SARS-CoV-2 vaccination. We analyzed factors related to vaccination efficiency in KTRs. In a multicenter prospective observational study (NCT04743947), IgG antibodies levels against SARS-CoV-2 spike S1 subunit and their neutralization capacity after SARS-CoV-2 vaccination were analyzed in 225 KTRs and compared to 176 controls.
View Article and Find Full Text PDF[De novo thombotic microangiopathy (TMA) after incompatible AB0 renal transplantation].
Dtsch Med Wochenschr
April 2021
Article Synopsis
- A 57-year-old patient underwent an ABO-incompatible living kidney transplant and developed signs of de novo Thrombotic Microangiopathy (TMA) three days post-op.
- Laboratory tests confirmed TMA and the patient’s kidney function showed stagnation despite initial treatment efforts.
- Administering eculizumab on days 3 and 10 post-surgery successfully managed the TMA, prompting a discussion about its early use to potentially prevent graft dysfunction and improve outcomes for transplant patients.