Gliomas are primary malignant brain tumors with a typically poor prognosis, exhibiting significant heterogeneity across different cancer types. Each glioma type possesses distinct molecular characteristics determining patient prognosis and therapeutic options. This study aims to explore the molecular complexity of gliomas at the transcriptome level, employing a comprehensive approach grounded in network discovery.
View Article and Find Full Text PDFMonitoring urban structure and development requires high-quality data at high spatio-temporal resolution. While traditional censuses have provided foundational insights into demographic and socio-economic aspects of urban life, their pace may not always align with the pace of urban development. To complement these traditional methods, we explore the potential of analysing alternative big-data sources, such as human mobility data.
View Article and Find Full Text PDFProgress in molecular methods has enabled the monitoring of bacterial populations in time. Nevertheless, understanding community dynamics and its links with ecosystem functioning remains challenging due to the tremendous diversity of microorganisms. Conceptual frameworks that make sense of time series of taxonomically rich bacterial communities, regarding their potential ecological function, are needed.
View Article and Find Full Text PDFIt has been postulated that the brain operates in a self-organized critical state that brings multiple benefits, such as optimal sensitivity to input. Thus far, self-organized criticality has typically been depicted as a one-dimensional process, where one parameter is tuned to a critical value. However, the number of adjustable parameters in the brain is vast, and hence critical states can be expected to occupy a high-dimensional manifold inside a high-dimensional parameter space.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
October 2022
The twin crises of climate change and biodiversity loss define a strong need for functional diversity monitoring. While the availability of high-quality ecological monitoring data is increasing, the quantification of functional diversity so far requires the identification of species traits, for which data are harder to obtain. However, the traits that are relevant for the ecological function of a species also shape its performance in the environment and hence, should be reflected indirectly in its spatiotemporal distribution.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
August 2022
Consider a cooperation game on a spatial network of habitat patches, where players can relocate between patches if they judge the local conditions to be unfavorable. In time, the relocation events may lead to a homogeneous state where all patches harbor the same relative densities of cooperators and defectors, or they may lead to self-organized patterns, where some patches become safe havens that maintain an elevated cooperator density. Here we analyze the transition between these states mathematically.
View Article and Find Full Text PDFCurrent questions in ecology revolve around instabilities in the dynamics on spatial networks and particularly the effect of node heterogeneity. We extend the master stability function formalism to inhomogeneous biregular networks having two types of spatial nodes. Notably, this class of systems also allows the investigation of certain types of dynamics on higher-order networks.
View Article and Find Full Text PDFMany current challenges involve understanding the complex dynamical interplay between the constituents of systems. Typically, the number of such constituents is high, but only limited data sources on them are available. Conventional dynamical models of complex systems are rarely mathematically tractable and their numerical exploration suffers both from computational and data limitations.
View Article and Find Full Text PDFThe Jacobian matrix of a dynamical system describes its response to perturbations. Conversely, one can estimate the Jacobian matrix by carefully monitoring how the system responds to environmental noise. We present a closed-form analytical solution for the calculation of a system's Jacobian from a time series.
View Article and Find Full Text PDFFront Neural Circuits
December 2021
The past decade has seen growing support for the critical brain hypothesis, i.e., the possibility that the brain could operate at or very near a critical state between two different dynamical regimes.
View Article and Find Full Text PDFEcological stability under environmental change is determined by both interspecific and intraspecific processes. Particularly for planktonic microorganisms, it is challenging to follow intraspecific dynamics over space and time. We propose a new method, microsatellite PoolSeq barcoding (MPB), for tracing allele frequency changes in protist populations.
View Article and Find Full Text PDFIn the Wireless Localization Matching Problem (WLMP) the challenge is to match pieces of equipment with a set of candidate locations based on wireless signal measurements taken by the pieces of equipment. This challenge is complicated by the noise that is inherent in wireless signal measurements. Here we propose the use of diffusion maps, a manifold learning technique, to obtain an embedding of positions and equipment coordinates in a space that enables coordinate comparison and reliable evaluation of assignment quality at very low computational cost.
View Article and Find Full Text PDFDispersal and foodweb dynamics have long been studied in separate models. However, over the past decades, it has become abundantly clear that there are intricate interactions between local dynamics and spatial patterns. Trophic meta-communities, i.
View Article and Find Full Text PDFThe rise in the availability of bacterial genomes defines a need for synthesis: abstracting from individual taxa, to see larger patterns of bacterial lifestyles across systems. A key concept for such synthesis in ecology is the niche, the set of capabilities that enables a population's persistence and defines its impact on the environment. The set of possible niches forms the niche space, a conceptual space delineating ways in which persistence in a system is possible.
View Article and Find Full Text PDFThe complexity of an ecological community can be distilled into a network, where diverse interactions connect species in a web of dependencies. Species interact directly with each other and indirectly through environmental effects, however to our knowledge the role of these ecosystem engineers has not been considered in ecological network models. Here we explore the dynamics of ecosystem assembly, where species colonization and extinction depends on the constraints imposed by trophic, service, and engineering dependencies.
View Article and Find Full Text PDFIdentifying stabilizing factors in foodwebs is a long standing challenge with wide implications for community ecology and conservation. Here, we investigate the stability of spatially resolved meta-foodwebs with far-ranging super-predators for whom the whole meta-foodwebs appears to be a single habitat. By using a combination of generalized modeling with a master stability function approach, we are able to efficiently explore the asymptotic stability of large classes of realistic many-patch meta-foodwebs.
View Article and Find Full Text PDFIn the twenty-first century, ongoing rapid urbanization highlights the need to gain deeper insights into the social structure of cities. While work on this challenge can profit from abundant data sources, the complexity of this data itself proves to be a challenge. In this paper, we use diffusion maps, a manifold learning method, to discover hidden manifolds in the UK 2011 census dataset.
View Article and Find Full Text PDFManufacturing supply networks are complex dynamic networks that play a crucial role in the economy. Nevertheless, there are so far only few studies that apply modern tools of network science and dynamical system theory to the analysis of these networks. Here, we provide a brief introduction to these types of networks highlighting their basic organization, current challenges, and selected previous work.
View Article and Find Full Text PDFAs impacts of introduced species cascade through trophic levels, they can cause indirect and counter-intuitive effects. To investigate the impact of invasive species at the network scale, we use a generalized food web model, capable of propagating changes through networks with a series of ecologically realistic criteria. Using data from a small British offshore island, we quantify the impacts of four virtual invasive species (an insectivore, a herbivore, a carnivore and an omnivore whose diet is based on a rat) and explore which clusters of species react in similar ways.
View Article and Find Full Text PDFSupply networks are exposed to instabilities and thus a high level of risk. To mitigate this risk, it is necessary to understand how instabilities are formed in supply networks. In this paper, we focus on instabilities in inventory dynamics that develop due to the topology of the supply network.
View Article and Find Full Text PDFWe study diffusion-driven pattern formation in networks of networks, a class of multilayer systems, where different layers have the same topology, but different internal dynamics. Agents are assumed to disperse within a layer by undergoing random walks, while they can be created or destroyed by reactions between or within a layer. We show that the stability of homogeneous steady states can be analyzed with a master stability function approach that reveals a deep analogy between pattern formation in networks and pattern formation in continuous space.
View Article and Find Full Text PDFThe spatial dispersal of individuals plays an important role in the dynamics of populations, and is central to metapopulation theory. Dispersal provides connections within metapopulations, promoting demographic and evolutionary rescue, but may also introduce maladapted individuals, potentially lowering the fitness of recipient populations through introgression of heritable traits. To explore this dual nature of dispersal, we modify a well-established eco-evolutionary model of two locally adapted populations and their associated mean trait values, to examine recruiting salmon populations that are connected by density-dependent dispersal, consistent with collective migratory behaviour that promotes navigation.
View Article and Find Full Text PDFIn ecology it is widely recognised that many landscapes comprise a network of discrete patches of habitat. The species that inhabit the patches interact with each other through a foodweb, the network of feeding interactions. The meta-foodweb model proposed by Pillai et al.
View Article and Find Full Text PDFThe study of epidemics on static networks has revealed important effects on disease prevalence of network topological features such as the variance of the degree distribution, i.e. the distribution of the number of neighbors of nodes, and the maximum degree.
View Article and Find Full Text PDFWe consider a class of adaptive network models where links can only be created or deleted between nodes in different states. These models provide an approximate description of a set of systems where nodes represent agents moving in physical or abstract space, the state of each node represents the agent's heading direction, and links indicate mutual awareness. We show analytically that the adaptive network description captures a phase transition to collective motion in some swarming systems, such as the Vicsek model, and that the properties of this transition are determined by the number of states (discrete heading directions) that can be accessed by each agent.
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