Whole-body integral dose and post-radiotherapy lymphocytopaenia in solid tumours.

Objective: Since modern radiotherapy techniques such as intensity-modulated radiotherapy (IMRT) pivot on a strategy of dose redistribution, it may increase integral dose and consequently worsening of lymphocytopaenia. In this study, our objective was twofold: first to validate the correlation between integral body dose and post-treatment lymphocytopaenia in a cohort of patients treated with curative-intent radiotherapy and second to validate its prognostic impact.

Methods And Analysis: Patients treated with curative intent radiotherapy with complete blood counts were included in the study.