Publications by authors named "Thies Bartram"
Background: Acute pancreatitis (AP) is a serious, mechanistically not entirely resolved side effect of L-asparaginase-containing treatment for acute lymphoblastic leukemia (ALL). To find new candidate variations for AP, we conducted a genome-wide association study (GWAS).
Methods: In all, 1,004,623 single-nucleotide variants (SNVs) were analyzed in 51 pediatric ALL patients with AP (cases) and 1388 patients without AP (controls).
Article Synopsis
- TCF3-HLF-positive acute lymphoblastic leukemia (ALL) is a serious disease that is currently very hard to cure.
- Researchers found unique changes in the genes and drug reactions of TCF3-HLF-positive ALL compared to another type, TCF3-PBX1-positive ALL.
- They discovered that certain genetic changes in TCF3 and PAX5 help explain why TCF3-HLF ALL is tougher to treat but also found possible new treatments that could be effective.
Acute lymphoblastic leukemia (ALL) accounts for ∼25% of pediatric malignancies. Of interest, the incidence of ALL is observed ∼20% higher in males relative to females. The mechanism behind the phenomenon of sex-specific differences is presently not understood.
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