[Application of the recommendations of the conference of consensus in front of symptoms ENT, respiratory or thoracic pains considered as due to a gastroesophageal reflux disease].

Aims: The primary objectives of this observatory were: (1) to assess the prevalence of extradigestive symptoms (EDS) (asthma, pharyngeal pain, chronic hoarseness, nocturnal breathlessness, chronic or nocturnal cough, non-cardiac chest pain) which are suspected of being associated with gastro-oesophageal reflux (GERD) in a population consulting in general practice; (2) to compare the diagnostic and therapeutic approach adopted initially and at follow-up to the recommendations of the French-Belgian Consensus Conference on adult GERD (1999).

Methods: The survey was conducted among 578 general practitioners (GPs). All EDS were investigated in patients (≥ 18 y.

Gastroesophageal reflux disease: impact on work productivity and daily-life activities of daytime workers. A French cross-sectional study.

Background: Few studies have evaluated the impact of gastroesophageal reflux disease symptoms on work productivity and no French data are available.

Aim: To compare the impact of typical symptoms of nocturnal vs diurnal gastroesophageal reflux disease on work productivity and daily activities.

Methods: A French prospective, multicenter, observational study was performed in primary care setting.

[Premalignant gastric lesions (except lymphomas)].

Atrophic gastritis, intestinal metaplasia, autoimmune corpus atrophic gastritis, gastric remnant man 15 years after gastrectomy, hyperplastic or adenoma polyps and gastric ulcer are conditions associated with an increased risk of gastric carcinoma of intestinal or diffuse type. The role of Helicobacter pylori infection is major but the usefulness of H. pylorieradication to revert precancerous lesions is questionable.

[Gastric polyps].

Gastric polyps exist in a wide variety of types, most often benign. Endoscopic discovery of gastric polyps necessitates biopsies - not only of the lesion but also of the antral and fundic mucosa to determine the therapeutic strategy and subsequent surveillance. Fundic gland polyps are the most frequent type; they are asymptomatic with no malignant potential.

Applicability and efficacy of qualifying criteria for an appropriate use of diagnostic upper gastrointestinal endoscopy.

Unlabelled: Appropriate indication for upper gastrointestinal endoscopy (UGE) may be facilitated by referring to qualifying criteria such as those devised by the European Panel (EPAGE) and French Experts (ANAES). This prospective study evaluates the applicability and efficacy of these criteria in clinical practice.

Patients And Methods: A total of 522 patients was included (55% inpatients, 57% male, mean age 55 years).

[New-generation proton pump inhibitors: progress in the treatment of peptic acid diseases?].

EFFECTS AND INCONVENIENCIES OF THE OLDER PRODUCTS: The proton pump inhibitors (PPIs) are now universally considered the treatment of choice for management of gastric-acid-related diseases, mainly gastro-oesophageal reflux disease (GERD). These drugs share similar properties: general structure, acid-activation step, covalent binding to the proton pump of the gastric parietal cell via the production of covalent disulphide bonds, relatively stable inhibition of H+,K+-ATPase. However, the older PPIs (omeprazole, lansoprazole et pantoprazole) have notable limitations.