The Oral Glucose Tolerance Test: Changed Results Using Different Drinking Solutions?

The impact of different drinking solutions used for an oral glucose tolerance test (oGTT) on 2-h glucose values and gastrointestinal side effects are not clear. This study compared a commercially produced solution (Accu-Chek Roche solution) and a standardized pharmacy solution (NRF 13.8.

Exoskeletons as potential devices to support and enhance rescuers' chest compression performance during out-of-hospital cardiac arrest.

Exoskeletons are wearable structures that support and assist movement, or augment the capabilities of the human body. These functionalities could theoretically assist bystanders or rescuers performing manual chest compressions during out-of-hospital cardiac arrest, as this emergency procedure is prone to physical exhaustion. Compressions are an intense muscular effort involving a dynamic muscular pattern with conflicting postural constraints.

Short-Term Metformin Protects Against Glucocorticoid-Induced Toxicity in Healthy Subjects: A Randomized, Double-Blind, Placebo-Controlled Trial.

Objective: Glucocorticoids (GCs) are potent anti-inflammatory drugs, but strategies to prevent side effects are lacking. We investigated whether metformin could prevent GC-related toxicity and explored the underlying mechanisms.

Research Design And Methods: This single-center, randomized, placebo-controlled, double-blind, crossover trial compared metformin with placebo during high-dose GC treatment in 18 lean, healthy, male study participants.

Technical Validation of a Spatial Tracking Configuration for Augmented and Co-Localized Medical Assistance Under Gravity Variations in Parabolic Flights.

Introduction: Augmented reality is a promising technology for enhancing remote medical assistance. It assists users by directly projecting the relevant virtual assistance in the real world at the right moment and at the right location. This modality is called colocalization but has not been validated in parabolic flights.

The Creation of an Individualized School Plan for Optimal Inclusion of Students with Osteogenesis Imperfecta.

Aims: The aims of this study were to: (1) synthesize existing evidence regarding the integration of students with osteogenesis imperfecta (OI) into the school setting, (2) tabulate existing school integration tools for OI, and (3) create an individualized school plan to facilitate school integration.

Methods: Guided by the process of developing evidence-informed guidelines, an international, interprofessional, expert task force was convened. The process entailed: (1) reviewing of the literature, (2) developing recommendations, and (3) creating a clinically meaningful, person-focused plan to facilitate the integration and promotion of school inclusivity.

Facial impressions of niceness influence children's interpretations of peers' ambiguous behavior.

Children infer personality traits from faces when they are asked explicitly which face appears nice or mean. Less is known about how children use face-trait information implicitly to make behavioral evaluations. We used the Ambiguous Situations Protocol to explore how children use face-trait information to form interpretations of ambiguous situations when the behavior or intention of the target child was unclear.

Health Service Use Among Migrants in the German National Cohort-The Role of Birth Region and Language Skills.

To compare health service use (HSU) between migrants and non-migrants in Germany. Using data from the population-based German National Cohort (NAKO), we compared the HSU of general practitioners, medical specialists, and psychologists/psychiatrists between six migrant groups of different origins with the utilization of non-migrants. A latent profile analysis (LPA) with a subsequent multinomial regression analysis was conducted to characterize the HSU of different groups.

Differences in Anthropometric Measures Based on Sex, Age, and Health Status: Findings From the German National Cohort (NAKO).

Background: Obesity is a worldwide health problem. We conducted detailed analyses of anthropometric measures in a comprehensive, population-based, current cohort in Germany.

Methods: In the German National Cohort (NAKO), we analyzed cross-sectional data on body mass index (BMI), waist and hip circumference, subcutaneous (SAT) and visceral adipose tissue (VAT) as measured by ultrasound, and body fat percentage.

Seropositivity of Borrelia burgdorferi s.l. in Germany-an analysis across four German National Cohort (NAKO) study sites.

Lyme borreliosis (LB) is caused by the transmission of Borrelia burgdorferi s.l. from ticks to humans.

Evaluation of free-floating tracheal intubation in weightlessness via ice-pick position with a direct laryngoscopy and classic approach with indirect videolaryngoscopy.

Long duration spaceflights to the Moon or Mars are at risk for emergency medical events. Managing a hypoxemic distress and performing an advanced airway procedure such as oro-tracheal intubation may be complicated under weightlessness due to ergonomic constraints. An emergency free-floating intubation would be dangerous because of high failure rates due to stabilization issues that prohibits its implementation in a space environment.

Signal quality indices evaluation for robust ECG signal quality assessment systems.

As the current healthcare system faces problems of budget, staffing, and equipment, telemedicine through wearable devices gives a means of solving them. However, their adoption by physicians is hampered by the quality of electrocardiogram (ECG) signals recorded outside the hospital setting. Due to the dynamic nature of the ECG and the noise that can occur in real-world conditions, Signal Quality Assessment (SQA) systems must use robust signal quality indices (SQIs).

A Chemically Defined TLR3 Agonist with Anticancer Activity.

Toll-like receptor 3 (TLR3) agonists such as polyinosinic:polycytidylic acid (poly(I:C)) have immunostimulatory effects that can be taken advantage of to induce anticancer immune responses in preclinical models. In addition, poly(I:C) has been introduced into clinical trials to demonstrate its efficacy as an adjuvant and to enhance the immunogenicity of locally injected tumors, thus reverting resistance to PD-L1 blockade in melanoma patients. Here, we report the pharmacokinetic, pharmacodynamic, mechanistic and toxicological profile of a novel TLR3 agonist, TL-532, a chemically synthesized double-stranded RNA that is composed by blocks of poly(I:C) and poly(A:U) (polyadenylic - polyuridylic acid).

TL-532, a novel specific Toll-like receptor 3 agonist rationally designed for targeting cancers: discovery process and biological characterization.

Toll-like receptor 3 (TLR3) is an innate immune receptor that recognizes double-stranded RNA (dsRNA) and induces inflammation in immune and normal cells to initiate anti-microbial responses. TLR3 acts also as a death receptor only in cancer cells but not in their normal counterparts, making it an attractive target for cancer therapies. To date, all of the TLR3-activating dsRNAs used at preclinical or clinical stages have major drawbacks such as structural heterogeneity, toxicity, and lack of specificity and/or efficacy.

A rare case of presumptive pleural toxocariasis.

Toxocariasis is a cosmopolitan helminthiasis linked to contamination with Toxocara cati or Toxocara canis. Only six isolated cases of pleural toxocariasis have been reported in the literature. We describe a case of pleurisy with isolated eosinophilia varying between 600 and 1500/mm likely linked o presumptive toxocariasis in a 72-year-old patient.

We need to move beyond rating scales, white faces and adult perceivers: Invited Commentary on Sutherland & Young (2022), understanding trait impressions from faces.

Sutherland and Young's perspective is a timely and rigorous examination of trait impressions based on facial cues. We propose three strtegies to further advance the field: incorporating natural language processing, including diverse facial stimuli, and re-interpreting developmental data.

Challenging Metastatic Melanoma to the Lung With p40 Expression: A Diagnostic Pitfall, Case Report.

p40 immunohistochemistry is a cornerstone of histopathological examination for non-small cell lung carcinoma. p40 is an isoform of p63 and is reported to be highly specific for the diagnosis of squamous cell carcinoma. Very rare pitfalls are reported for this antibody, and p40 is typically negative in melanoma.

Framework and baseline examination of the German National Cohort (NAKO).

The German National Cohort (NAKO) is a multidisciplinary, population-based prospective cohort study that aims to investigate the causes of widespread diseases, identify risk factors and improve early detection and prevention of disease. Specifically, NAKO is designed to identify novel and better characterize established risk and protection factors for the development of cardiovascular diseases, cancer, diabetes, neurodegenerative and psychiatric diseases, musculoskeletal diseases, respiratory and infectious diseases in a random sample of the general population. Between 2014 and 2019, a total of 205,415 men and women aged 19-74 years were recruited and examined in 18 study centres in Germany.

Influence of 30 and 60 Min of Hypobaric Hypoxia in Simulated Altitude of 15,000 ft on Human Proteome Profile.

The human body reacts to hypobaric hypoxia, e.g., during a stay at high altitude, with several mechanisms of adaption.

Randomized Comparison of Two New Methods for Chest Compressions during CPR in Microgravity-A Manikin Study.

Background: Although there have been no reported cardiac arrests in space to date, the risk of severe medical events occurring during long-duration spaceflights is a major concern. These critical events can endanger both the crew as well as the mission and include cardiac arrest, which would require cardiopulmonary resuscitation (CPR). Thus far, five methods to perform CPR in microgravity have been proposed.

Using supraglottic airways by paramedics for airway management in analogue microgravity increases speed and success of ventilation.

In the next few years, the number of long-term space missions will significantly increase. Providing safe concepts for emergencies including airway management will be a highly challenging task. The aim of the present trial is to compare different airway management devices in simulated microgravity using a free-floating underwater scenario.

First impressions of child faces: Facial trustworthiness influences adults' interpretations of children's behavior in ambiguous situations.

Despite the profound behavioral consequences that first impressions of trustworthiness have on adult populations, few studies have examined how adults' first impressions of trustworthiness influence behavioral outcomes for children. Using a novel task design, we examined adults' perceptions of children's behavior in ambiguous situations. After a brief presentation of a child's face (high trust or low trust), participants viewed the child's face embedded within an ambiguous scene involving two children (Scene Task) or read a vignette about a misbehavior done by that child (Misbehavior Task).

Mandatory First Impressions: Happy Expressions Increase Trustworthiness Ratings of Subsequent Neutral Images.

First impressions of traits are formed rapidly and nonconsciously, suggesting an automatic process. We examined whether first impressions of trustworthiness are mandatory, another component of automaticity in face processing. In Experiment 1a, participants rated faces displaying subtle happy, subtle angry, and neutral expressions on trustworthiness.