Publications by authors named "Thien T P Dao"
Article Synopsis
- Scientists found that a bad version of a gene called FUS causes some really serious types of ALS, a disease that affects muscles and movement.
- The FUS gene gets too tangled with another protein called H1.2, which can make the disease worse, but if scientists lower the levels of H1.2 or stop a process called PARylation, it can help reduce the problems caused by FUS.
- In tiny worms called C. elegans, cutting down on H1.2 and a similar protein helped stop the FUS problems, showing us that learning about these relations can help us find treatments for ALS.
Article Synopsis
- Acute myeloid leukemia (AML) has a poor prognosis, even with new treatments, prompting researchers to seek new druggable pathways, specifically focusing on SUMOylation through extensive bioinformatic analysis of large AML databases.
- The SUMOylation pathway was validated as clinically relevant, revealing correlations with patient survival and AML-associated mutations, and the SUMOylation inhibitor TAK-981 demonstrated significant antileukemic effects, outperforming the standard treatment drug, cytarabine.
- TAK-981 showed effectiveness in multiple models and has distinct mechanisms of action compared to previous treatments, suggesting SUMOylation could be a new target for AML therapy and highlighting the need for further clinical studies.
Background: Clear cell renal cell carcinoma (ccRCC), with its hallmark phenotype of high cytosolic lipid content, is considered a metabolic cancer. Despite the implication of this lipid-rich phenotype in ccRCC tumorigenesis, the roles and regulators of de novo lipid synthesis (DNL) in ccRCC remain largely unexplained.
Methods: Our bioinformatic screening focused on ccRCC-lipid phenotypes identified glutathione peroxidase 8 (GPX8), as a clinically relevant upstream regulator of DNL.
Despite growing evidence for mitochondria's involvement in cancer, the roles of specific metabolic components outside the respiratory complex have been little explored. We conducted metabolomic studies on mitochondrial DNA (mtDNA)-deficient (ρ0) cancer cells with lower proliferation rates to clarify the undefined roles of mitochondria in cancer growth. Despite extensive metabolic downregulation, ρ0 cells exhibited high glycerol-3-phosphate (G3P) level, due to low activity of mitochondrial glycerol-3-phosphate dehydrogenase (GPD2).
View Article and Find Full Text PDFObjective: This study aimed to evaluate the protective effect of igalan, a sesquiterpene lactone isolated from Inula helenium (L.), on inhibiting inflammation, regulating the epidermal differentiation gene expression, and reactive oxygen species scavenging in atopic dermatitis (AD)-like inflammatory keratinocytes.
Methods: HaCaT human keratinocytes were treated with igalan at indicated concentrations before being activated by a combination of TNF-α and IFN-γ or IL-4 representative for T-helper 1 and T-helper 2 cell cytokines, which are associated with AD pathogenesis.
This research aimed to investigate the cytotoxicity of methanol extract of leaf (YLE) against a human hepatocellular carcinoma cell line (HepG2). This plant is currently used as a traditional herbal remedy in the treatment of liver diseases in some rural parts of Myanmar. : The cytotoxic activity of the plant extract against the cancerous cell line was assessed using an MTT assay.
View Article and Find Full Text PDFLeaf Extract Triggered Intrinsic Apoptotic Pathway to Attenuate Cancerous Features of Triple Negative Breast Cancer MDA-MB-231 Cells.
Evid Based Complement Alternat Med
July 2018
L., known as graviola, is an evergreen plant of the tropical regions and is a rich source of natural products. Graviola has various biological activities, and it is best known for its anticancer activity.
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