Publications by authors named "Thibaut Snollaerts"
Article Synopsis
- Painful experiences are complex and have sensory, emotional, cognitive, and behavioral aspects, with chronic pain often linked to changes in neuron function, although the molecular details remain unclear.
- Brain-derived neurotrophic factor (BDNF) plays a significant role in pain by enhancing neuron activity, particularly in areas like the anterior cingulate cortex (ACC) and primary sensory cortex (S1), which are involved in pain perception.
- In experiments, increasing BDNF levels led to heightened neuron excitability and pain sensitivity; conversely, blocking BDNF signaling reduced these effects, highlighting the importance of BDNF in the emotional aspects of chronic pain.
The aggregation of the 37-residue protein, islet amyloid polypeptide (IAPP), as either insoluble amyloid or as small oligomers, appears to play a direct role in the death of pancreatic beta-islet cells in type II diabetes. While IAPP has been known to be the primary component of type II diabetes amyloid, the molecular interactions responsible for this aggregation have not been identified. To identify the aggregation-prone region(s), we constructed a library of randomly generated point mutants of IAPP.
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