Publications by authors named "Thibaut Leclercq"
Article Synopsis
- Heterozygous dominant-negative mutations are linked to a common form of hyper-immunoglobulin E syndrome (HIES), while a newly identified autosomal recessive form is caused by loss-of-function mutations in the ZNF341 gene.
- ZNF341 is crucial as a transcription factor in the nucleus, where it binds to DNA to regulate various genes, including those involved in immune response.
- Patients lacking ZNF341 show impaired production and function of STAT3, leading to deficiencies in specific immune cells and altered inflammatory responses.
