Publications by authors named "Thibaut Goldsborough"
Background: Epigenetic scores (EpiScores) can provide biomarkers of lifestyle and disease risk. Projecting new datasets onto a reference panel is challenging due to separation of technical and biological variation with array data. Normalisation can standardise data distributions but may also remove population-level biological variation.
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- The study addresses challenges in analyzing imaging mass cytometry (IMC) data, particularly issues with accurate single-cell segmentation and visualization, which can lead to misidentification of cell types and states.
- Researchers developed the OPTIMAL framework to systematically evaluate various methods for cell segmentation, data transformation, and clustering on a human tonsil tissue sample stained with 27 antibodies over multiple batches.
- Key findings include improved single-cell segmentation using a probability map, optimal data transformation with an arcsinh cofactor of 1, and the effectiveness of the PacMap dimensionality reduction technique combined with FLOWSOM clustering for better cell type identification.