Publications by authors named "Thibault Poinsot"
Front Microbiol
December 2024
Article Synopsis
- Type 1 diabetes (T1D) results from an autoimmune attack that destroys insulin-producing beta cells, with its initiation linked to genetic, immunological, and environmental factors, particularly viral infections like Coxsackievirus B (CVB).
- Research reveals that CVB serotype 1 (CVB1) may trigger autoimmune responses in genetically susceptible individuals, but the exact mechanisms of its replication in beta cells are unclear.
- New findings indicate that the N6-methyladenosine (m6A) modification influences CVB1 amplification, where downregulating m6A "writers" increases viral replication, while inhibiting "erasers" like FTO significantly decreases infectious CVB1 production, highlighting m6A's role
