Publications by authors named "Thibault Fraisse"
Familial Mediterranean fever (FMF) patients may have hepatic cytolysis, although its origin is not formally elucidated. We aimed to evaluate liver involvement in familial Mediterranean fever (FMF) using non-invasive methods. All adult FMF patients harboring two non-ambiguous mutations of the MEFV gene with hepatic cytolysis were identified in a French tertiary adult center for FMF.
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- Familial Mediterranean fever (FMF) is an autoinflammatory disease linked to MEFV gene mutations, leading to symptoms like fever and abdominal inflammation, with unclear liver impacts.
- A systematic review of studies from 1946 to January 2020 revealed various liver conditions associated with FMF, including nonalcoholic fatty liver disease (NAFLD) and cryptogenic cirrhosis among patients.
- Regular liver screenings for FMF patients are recommended, and preventive treatment options like daily colchicine use may help mitigate liver injury risks.
Objectives: Familial Mediterranean fever (FMF) can be complicated by AA amyloidosis (AAA), though it remains unclear why only some patients develop amyloidosis. We examined the gut microbiota composition and inflammatory markers in patients with FMF complicated or not by AAA.
Methods: We analysed the gut microbiota of 34 patients with FMF without AAA, 7 patients with FMF with AAA, 19 patients with AAA of another origin, and 26 controls using 16S ribosomal RNA gene sequencing with the Illumina MiSeq platform.
Article Synopsis
- Vemurafenib, a BRAF inhibitor approved for melanoma treatment, has greatly improved survival rates compared to traditional therapies and initially did not show kidney-related side effects.
- A case series involving 8 patients has revealed that vemurafenib can lead to severe renal insufficiency in some individuals.
- It is important to monitor kidney function closely in patients undergoing vemurafenib treatment to catch any potential renal issues early on, as further research is needed to understand its effects on the kidneys.