Ru(ii)/Os(ii)-based carbonic anhydrase inhibitors as photodynamic therapy photosensitizers for the treatment of hypoxic tumours.

Photodynamic therapy (PDT) is a medical technique for the treatment of cancer. It is based on the use of non-toxic molecules, called photosensitizers (PSs), that become toxic when irradiated with light and produce reactive oxygen specious (ROS) such as singlet oxygen (O). This light-induced toxicity is rather selective since the physician only targets a specific area of the body, leading to minimal side effects.

A biomimetic cerium-based biosensor for the direct visual detection of phosphate under physiological conditions.

An indicator displacement assay (IDA) was used to probe phosphate ions in an aqueous medium at neutral pH using a dinuclear cerium based complex [Ce2(HXTA)]3+. The homoleptic complex can be used to detect phosphate ions with nanomolar affinity either spectrophotometrically or with the naked-eye. To our knowledge, this is the first dinuclear cerium biomimetic IDA detection system with the highest affinity known to date for selective, naked-eye based phosphate recognition under physiological conditions (pH = 5-7) and even in pure water and complex samples such as sea water.

«La Chimie en Couleurs»: Socially Relevant & Original Research in Chemistry in High Schools Using Modest Resources.

Teaching chemistry at high school level has the potential of playing a major role for the development of our society, in particular, to form future leaders in chemistry who will address social challenges such as the need for better healthcare, improved agricultural techniques and more efficient use of energy resources. In general, high school chemistry teaching programs tend to illustrate the great historic discoveries and glorious past of chemical research. It is hoped that this historical perspective will help to provide students with the basic understanding necessary for the development of the chemistry of tomorrow.