Publications by authors named "Thiago Ubiratan Lins E Lins"
Evaluation of Antibacterial, Antineoplastic, and Immunomodulatory Activity of Seeds Crude Extract and Ethyl-Acetate Fraction.
Evid Based Complement Alternat Med
December 2016
Article Synopsis
- Guarana seeds are rich in bioactive compounds like tannins and have traditional significance in the Amazon region.
- The study examined the antibacterial, antineoplastic, and immunomodulatory properties of crude extract (CE) and ethyl-acetate fraction (EAF) from these seeds.
- Results indicated that CE and EAF exhibited bacteriostatic activity and reduced cytokine levels in treated cells, showing potential for therapeutic applications in various diseases due to their bioactive nature.
Introduction: Gout is considered to be an autoinflammatory disease and the presence of monosodium urate (MSU) crystals stimulates activation of NPRL3 inflammasome and subsequently caspase-1, generating production of active IL-1β and IL-18. However, the association between serum cytokines levels and clinical manifestations of the disease is not yet well understood. We evaluated the serum profile of proinflammatory cytokines (IL-1β, IL-6, IL-8, IL-17A, IL-18, IL-22, and IL-23) and described their relationship with clinical and laboratory data.
View Article and Find Full Text PDFEvaluation of Th17-related cytokines and IFNγ production from blood mononuclear cells of moderate and severe asthmatic children reveals methylprednisolone does not decrease IL-22 levels.
J Asthma
April 2015
Objective: The aim of this study was to correlate IL-6, IL-17A, IFNγ, and IL-22 production with asthma disease severity and to evaluate if methylprednisolone downregulated cytokine production in peripheral blood mononuclear cells (PBMCs).
Methods: Forty-two children with chronic persistent asthma and 34 non-asthmatic children were selected. Cytokines were quantified by ELISA from serum or PBMCs supernatants, after the PMA and Ionomycin stimulation, with or without methylprednisolone at 100 µM.