Prevalence of the variants p.R229Q, p.A242V, and p.R138Q in patients with focal segmental glomerulosclerosis.

Background: gene variants are associated with focal segmental glomerulosclerosis (FSGS) and steroid-resistant nephrotic syndrome (SRNS). In this study, the prevalence of variants p.R229Q, p.

Markers of renal fibrosis: How do they correlate with podocyte damage in glomerular diseases?

Background: Renal fibrosis is the result of the interaction of cellular and molecular pathways, which is induced by sustained glomerular injury and involves the podocytes and multiple profibrotic factors. In this study, we investigated the correlation of the mRNA expression of podocyte proteins and profibrotic factors with renal fibrosis measured in renal biopsies of patients with primary and secondary glomerulopathies.

Methods: Eighty-four adult patients with primary or secondary glomerular diseases and 12 controls were included.