Publications by authors named "Thiago Pereira Henriques"
We determined the antioxidant potential of fractions obtained from leaves of , a medicinal plant known in Brazil as aroeira, to select the fraction with the best yield and antioxidant performance. These qualities were found in the methanol fraction (MeF), which was administered intraperitoneally (20 mg/kg/day) for 3 and 10 days to rats with chronic constriction injury (CCI) of the sciatic nerve, a model of neuropathic pain. The MeF increased the mechanical and thermal thresholds that had been lowered by CCI.
View Article and Find Full Text PDFThe first 2 weeks of life are a critical period for neural development in rats. Repeated long-term separation from the dam is considered to be one of the most potent stressors to which rat pups can be exposed, and permanently modifies neurobiological and behavioral parameters. Prolonged periods of maternal separation (MS) usually increase stress reactivity during adulthood, and enhance anxiety-like behavior.
View Article and Find Full Text PDFArticle Synopsis
- - The study explored how prenatal stress from maternal restraint affects the social behavior and anxiety of offspring, particularly focusing on specific brain neurons involved in the release of oxytocin (OT) and vasopressin (VP).
- - It found that male offspring from stressed mothers displayed impaired social memory and increased anxiety, especially in the group where both mother and pup experienced stress (S:S), which correlated with a decrease in OT and VP-positive neurons in certain brain areas.
- - The results emphasize the significance of the prenatal period, suggesting that stress during pregnancy can lead to long-term behavioral issues in adult offspring, although alterations in the peptidergic systems only partially explain these deficits.