Publications by authors named "Thiago Moreno Souza"
Background: According to the last 2023 Monkeypox (Mpox) Outbreak Global Map from the Centres for Disease Control and Prevention (CDC), more than 100 countries with no Mpox infection report cases. Brazil stands out in this group and is the second country with the highest number of cases in the last outbreak.
Objective: To contribute to knowledge of the virus infection effects in a cellular model, which is important for diagnosis infections not yet included in a provider´s differential diagnosis and for developing viral inhibition strategies.
Article Synopsis
- The influenza virus can cause serious seasonal infections globally, affecting people of all ages and leading to significant public health issues, particularly in high-risk groups.
- Vaccination is the most effective prevention method, while oseltamivir is the primary antiviral treatment; however, resistance to this drug is becoming a concern, highlighting the need for alternative treatments.
- Research in Brazil is exploring the antiviral potential of microalgae and cyanobacteria, with studies showing that certain extracts can inhibit influenza replication and remain effective against resistant strains.
The effects of the diterpenes isolated from the Brazilian brown algae Dictyota pfaffii and Dictyota menstrualis against the herpes simplex type-1 replicative cycle.
Planta Med
March 2010
We describe in this paper that the diterpenes 8,10,18-trihydroxy-2,6-dolabelladiene ( 1) and (6 R)-6-hydroxydichotoma-4,14-diene-1,17-dial ( 2), isolated from the marine algae DICTYOTA PFAFFII and D. MENSTRUALIS, respectively, inhibited HSV-1 infection in Vero cells. We initially observed that compounds 1 and 2 inhibited HSV-1 replication in a dose-dependent manner, resulting in EC (50) values of 5.
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