Publications by authors named "Thiago Andrade Patente"
Article Synopsis
- * It was found that inhibiting microsomal prostaglandin E synthase-1 (mPGES) disrupts Th2 priming, emphasizing the importance of Prostaglandin E2 (PGE2) in this immune response mechanism.
- * The research highlights potential drug targets to manage helminth-induced Th2 responses and shows that blocking PGE2 after immunization reduces egg-specific T cell responses.
Article Synopsis
- Short-chain fatty acids (SCFAs), particularly acetate, play a critical role in enhancing immune responses by activating macrophages in the lungs to fight bacterial infections.
- The study reveals that acetate influences macrophage behavior through changes in gene expression, metabolic processes, and boosts nitric oxide production, which is essential for their bactericidal activity.
- Notably, acetate's effects are linked to the NLRP3 inflammasome and HIF-1α activation via enhanced glycolysis, rather than through traditional receptor pathways or metabolism enzymes.
Article Synopsis
- * Research on peritoneal macrophages from diabetic mouse models and human T1D patients revealed an increased inflammatory response, characterized by elevated cytokines and nitric oxide production, which was reduced by docosahexaenoic acid (DHA) treatment.
- * The study suggests that DHA could potentially serve as an additional therapy to lessen the inflammatory state in T1D by downregulating pro-inflammatory pathways in macrophages.
As cancer immunotherapy gains importance, the determination of a patient's ability to react to his/her tumor is unquestionably relevant. Though the presence of T cells that recognize specific tumor antigens is well established, the total frequency of tumor-reactive T cells in humans is difficult to assess, especially due to the lack of broad analysis techniques. Here, we describe a strategy that allows this determination, in both CD4 and CD8 compartments, using T cell proliferation induced by tumor cell-lysate pulsed dendritic cells as the readout.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the link between oxidative stress and diabetic retinopathy (DR) in individuals with type 1 diabetes (T1D), focusing on specific genetic variations (SNPs) in antioxidant genes.
- It involved 288 participants, categorized by DR stages, and utilized real-time PCR for genetic analysis along with logistic regression to account for other influencing factors.
- Findings revealed that the T-allele of rs17883901 increases the risk of proliferative DR while the T-allele of rs713041 offers protection against it, highlighting the potential role of these SNPs in DR management.
Cardiac autonomic neuropathy is a neglected diabetic chronic complication for which genetic predictors are rarely reported. Oxidative stress is implicated in the pathogenesis of microvascular complications, and glutathione peroxidase 4 is involved in the detoxification of peroxides and of reactive oxygen species. Thus, the association of a functional variant in the gene encoding glutathione peroxidase 4 (rs713041) with this diabetic complication was investigated in 341 individuals with type 1 diabetes evaluated for cardiac autonomic neuropathy status (61.
View Article and Find Full Text PDFAlthough inflammasome plays a well-known role in animal models of renal injury, limited studies in humans are available, and its participation in diabetic kidney disease (DKD) remains unknown. Aim of this study was to elucidate the contribution of inflammasome genetics in the development of DKD in type-1 diabetes (T1D). The association of functional variants in inflammasome genes with DKD was assessed by multivariate analysis in a retrospective and in a prospective cohort.
View Article and Find Full Text PDF