Determination of enantiomeric impurity of tenofovir disoproxil fumarate on a cellulose tris(3,5-dichlorophenyl-carbamate) chiral stationary phase and the characterization of its related substances.

A simple and reliable high-performance liquid chromatography method was developed to determine the enantiomeric impurity of tenofovir disoproxil fumarate, an orally bioavailable prodrug of tenofovir, commonly used for the treatment of human immunodeficiency virus and hepatitis B. Tenofovir disoproxil and its enantiomer, were completely separated on a Chiralpak IC column (3 μm, 100 × 4.6 mm, i.

Two new phenolic compounds from the Vietnamese lichen .

Chemical investigation of the lichen (Nyl.) Hale led to the isolation of two new phenolic compounds, 2-ethylhexyl orsellinate () and tinctorinone (). The structures were determined by analysis of their MS and NMR data as well as by comparison with literature data.