Publications by authors named "Thi Tuong Vi Dang"

Alternative transcription start site (TSS) usage regulation has been identified as a major means of gene expression regulation in metazoans. However, in fungi, its impact remains elusive as its study has thus far been restricted to model yeasts. Here, we first re-analyzed TSS-seq data to define genuine TSS clusters in 2 species of pathogenic Cryptococcus.

View Article and Find Full Text PDF

Resistance to fluconazole (FLC), the most widely used antifungal drug, is typically achieved by altering the azole drug target and/or drug efflux pumps. Recent reports have suggested a link between vesicular trafficking and antifungal resistance. Here, we identified novel regulators of extracellular vesicle (EV) biogenesis that impact FLC resistance.

View Article and Find Full Text PDF
Article Synopsis
  • Plants have a specialized secondary metabolism that produces flavonoids like anthocyanins, which aid in pollination and protect against environmental stresses.
  • The biosynthesis of anthocyanins is regulated by a transcriptional complex and is triggered by factors like high sucrose levels, but it is also energy-intensive and non-essential for survival.
  • The SnRK1 protein kinase acts as a metabolic sensor that represses anthocyanin production during energy-depleting conditions by affecting the MBW complex, leading to decreased transcription and protein degradation.
View Article and Find Full Text PDF

Pathogenic fungi require delicate gene regulation mechanisms to adapt to diverse living environments and escape host immune systems. Recent advances in sequencing technology have exposed the complexity of the fungal genome, thus allowing the gradual disentanglement of multiple layers of gene expression control. Alternative transcription start site (aTSS) usage, previously reported to be prominent in mammals and to play important roles in physiopathology, is also present in fungi to fine-tune gene expression.

View Article and Find Full Text PDF