Publications by authors named "Thi Trang Dai Vo"
Article Synopsis
- Streptococcus pneumoniae, Haemophilus influenzae, and Neisseria meningitidis are major causes of preventable bacterial meningitis in children, with vaccines available to combat these diseases.
- A study was conducted in three pediatric hospitals in Vietnam from 2015 to 2018 to gather data on the impact of pneumococcal meningitis and its serotype distribution, which is important for the introduction of pneumococcal conjugate vaccines (PCVs).
- Out of 1,803 suspected cases, 245 were confirmed as bacterial meningitis, with a high prevalence (93.5%) of cases caused by S. pneumoniae, predominantly from serotypes included in existing PCVs (most notably ser
Article Synopsis
- Researchers are exploring reduced-dose schedules of pneumococcal conjugate vaccines (PCV) to lower costs and improve accessibility in low and middle-income countries.
- Initial findings indicate that after vaccination at 12 months, memory B cell responses were stronger in those who received a 1 + 1 schedule compared to a 0 + 1 schedule, as well as for PCV13 compared to PCV10.
- The study highlights the need for further research on the long-term protective effects of B cells against pneumococcal disease to inform immunization program decisions.
Background: Preterm infants are more likely to experience severe respiratory syncytial virus (RSV) disease compared to term infants. The reasons for this are multi-factorial, however their immature immune system is believed to be a major contributing factor.
Methods: We collected cord blood from 25 preterm (gestational age 30.
Article Synopsis
- Preterm infants are more vulnerable to severe infections than full-term infants, possibly due to their ability to respond to pathogens, with limited research on their viral response specifically.
- The study examined immune responses in cord blood mononuclear cells from preterm and term infants, comparing their reactions to various Toll-like receptor (TLR) agonists, revealing similar baseline TLR expression but different activation patterns.
- While both preterm and term infants displayed comparable responses, preterm infants had increased monocyte activation to certain bacterial stimuli, but did not match the higher levels of immune response seen in adults, indicating a need for further research to address infection risks in preterm infants.