Publications by authors named "Thi Thanh Dinh"
Article Synopsis
- Anaplastic lymphoma kinase (ALK) is a key target for cancer treatment, and NVP-TAE684, an ALK inhibitor, shows promise in fighting various cancers, including pancreatic adenocarcinoma.
- In this study, NVP-TAE684 effectively reduced the growth of pancreatic cancer cells, leading to increased cell death and cell cycle arrest by disrupting the ALK signaling pathway.
- The research also demonstrated that combining NVP-TAE684 with gemcitabine, a common chemotherapy drug, significantly enhanced the treatment's effectiveness against cancer cells.
Background: There are currently two markers used to monitor treatment response to anti-retroviral therapy (ART) in HIV-infected children: CD4 T-cell count and HIV viral load; but analysis of these could be challenging in resource-poor countries. The aim of this study was therefore to determine whether change in growth parameters such as weight-for-age Z score (WAZ), height-for-age Z score (HAZ) and body mass index-for-age Z score (BMIZ) is associated with treatment response in HIV-infected children.
Methods: This was a nested case-control study, in which the data were collected at enrolment and then periodically every 6 months for a total 36 month follow up of 107 HIV-infected children enrolled and treated at National Hospital of Pediatrics, Vietnam.
Objectives: Over the past decades, Vietnam has made great strides in reducing the rate of mortality in HIV-related deaths, due to increased access of antiretroviral therapy (ART); however, given the significantly high level of treatment failure (TF), it is essential to identify markers that describe the failure of ART in HIV-1 infected children.
Methods: A nested case-control study was conducted with clinical data collected from 101 HIV-infected children [26 TF and 75 treatment success (TS)] at National Hospital of Pediatrics, Vietnam (2008-2012).
Results: The results showed that certain factors including height, weight, vaccination with Hepatitis B, and platelet were significantly different between TF and TS before starting the treatment.