A new cucurbitane - type triterpenoid from the bark of Kurz.

A new cucurbitacin, 3-(-D-glucopyranosyloxy)-5,6:16,23-diepoxycucurbit-24-en-11-one or hygrocucurbin A , along with two known compounds, including 3-(-D-glucopyranosyloxy)-16,23-epoxycucurbita-5,24-dien-11-one and (+)-lyoniresinol , were isolated from the bark of . Their chemical structures were elucidated by spectroscopic NMR, HR-IDA- TOF-MS analysis, and by comparison with the spectral data of corresponding compounds in the literature. Two cucurbitacins and were evaluated for their -glucosidase inhibitory activity and cytotoxic against KB, MCF-7, Hep G2, and A549 cancer cell lines.

Spermacosides a and B, two new triterpenoid saponins from burm.f.

Two new triterpenoid saponins, named spermacosides A-B (-), together with two known oleanane-type triterpenoid saponins, 3--D-xylopyranosyl-(1→3)-D-glucopyranosylbayogenin ( and 3---D-glucopyranosylbayogenin (), were isolated from the ethyl acetate extract of Burm.f. in a phytochemical investigation.

Jasminanthoside - a new pregnane-steroid from .

A new pregnane steroid, jasminanthoside (), together with three known compounds, telosmoside A7 (), syringaresinol (), and methyl 6-deoxy-3--methyl--D-allopyranosyl-(1→4)--D-oleandropyranoside () were isolated from the ethyl acetate extract of roots collected in Vietnam. Their chemical structures were elucidated by NMR and MS spectroscopic data analysis along with the comparison of their data with the published ones in the literature. Although was a known compound, its full NMR data were reported for the first time.

Cafestol analogues from : inhibition and molecular docking to -glucosidase.

A new cafestol-type diterpenoid, 5-hydroxy-2-oxocafestol named coffecanepholide C () along with three known diterpenoids including cafestol , tricalysiolide A () and atractyligenin () were identified from the trunks collected at Lam Dong province, Vietnam. Their structures were elucidated by HRESIMS and NMR spectroscopic analysis (H, C, COSY, HSQC, HMBC, and NOESY NMR) as well as compared with data in the literature. Upon evaluation of the -glucosidase inhibitory activity, compound (IC = 142.

Control of Obesity, Blood Glucose, and Blood Lipid with Roxb. Root Extract in High-Fat Diet-Induced Obese Mice.

Mice were used in experiments to evaluate the effects of doses of -hexane extract (from 100 to 1,300 mg/kg body weight/day) on the ability to control obesity, blood glucose, and blood lipid. In this study, body weight gain, caloric intake, glucose tolerance, blood lipid, histopathological study, and locomotion activity were examined. Furthermore, this study evaluated the lethality of the extract in extremely high doses in the tested mice.

A and B: two new oleanane saponins from the aerial parts of .

Two new oleanane saponins, hedyocoronin A and hedyocoronin B (), were isolated from the aerial parts of (Kurz) Craib, Rubiaceae, collected at Da Oai district, Lam Dong province in Vietnam. Their chemical structures were elucidated by HR-MS, 1D and 2D-NMR spectra, along with the comparison with those reported in the literature. Compounds and showed weak cytotoxicity against KB and HeLa-S3 cancer cell lines with IC values of more than 54 µM.

Two new -kaurane-type diterpene diastereomers isolated from .

Phytochemical investigation of the trunks of yielded two new kaurane diterpene diastereomers, which have been named coffecanepholide A, 3,16,17-trihydroxykauran-18-al () and coffecanepholide B, -3,16,17-trihydroxykauran-19-al (). Structural elucidation and configurational assignment were deduced from extensive spectroscopic NMR/HRESIMS analysis and by comparison with the spectral data of the literature relevant structures. The isolated compounds were assayed for inhibitory activities against -glucosidase.

Lasibidoupins A and B, two new compounds from the stems of V.S. Dang & Naiki.

From the stems, two new compounds, including one new 9,10-anthraquinone, lasibidoupin A (), and one new 6,7-benzocoumarin, lasibidoupin B (), together with one known compound, 11--methyldamnacanthol () were isolated using chromatographic method. Their structures were determined by extensive HRMS, and NMR assignments. Compound was reported for the first time from this species.

A new oleanane-skeleton triterpene isolated from .

Extensive fractionation of -hexane extract from the dried powdered-trunks of Pierre ex A.Froehner (Rubiaceae) led to the isolation of a new oleanane-skeleton triterpene, coffecanolic acid (), along with three known analogues sumaresinolic acid (), oleanolic acid (), and 3--acetyloleanolic acid (). The chemical structures were elucidated using FT-IR, 1D and 2D NMR and HR-ESI-MS data analysis.

Lignans and triterpenes from the root of Pseuderanthemum carruthersii var. atropurpureum.

Two new lignans, pseuderesinol (1), pseuderanoside (2) and a new triterpene, pseuderanic acid (3) were isolated from the dried root of Pseuderanthemum carruthersii (SEEM.) GUILL. var.