Publications by authors named "Thi My Nuong Nguyen"
Previous results from the our research group have isolated numerous compounds, including novel ones, but the anticancer activity of has not been demonstrated. In this study, from the most active ethyl acetate extract of the stems of , seven compounds were isolated and determined structures, including a new drimane sesquiterpenoid compound named miliutine C methyl ester () and three bioactive alkaloids (-). These three alkaloids (-) exhibited strong anticancer activities against various cancer cell lines such as MCF-7, HepG2, HeLa, NCI H460 and normal fibroblasts.
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- Vietnamese ginseng (Ngoc Linh ginseng) is a unique plant species native to Vietnam, from which five compounds were extracted and studied.
- Among these compounds, one new sesquiterpene lactone, panaxolide, was identified alongside four known compounds, using various advanced spectral techniques for structural analysis.
- In tests for cancer treatment potential, panaxolide demonstrated significant effectiveness, inhibiting the growth of HepG2 cancer cells with an IC value of 63.8 μM, more effectively than the other compounds tested.
Genetic Determinants and Genotype-Phenotype Correlations in Vietnamese Patients With Dilated Cardiomyopathy.
Circ J
August 2021
Article Synopsis
- The study analyzed the genetic factors associated with dilated cardiomyopathy (DCM) in 230 Vietnamese patients, finding a 23.5% diagnostic yield among familial and sporadic cases.
- It identified TTN truncating variants as the most common genetic alteration, especially in younger patients, and established that genotype-positive individuals often experienced more severe cardiac issues compared to those with negative results.
- The research highlights the importance of understanding the genetic landscape of DCM in Vietnam and suggests that addressing environmental factors may improve patient outcomes.
From the ethyl acetate extract of the stems of , seven compounds (-) were isolated, including two new compounds such as mivelutina A acid (), mivelutina B acid () and one known compound mivelutina B methyl ester (). For this NMR data were not known previously. Their relative structures were elucidated based on NMR spectroscopic analysis.
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