An international core outcome set for primary progressive aphasia (COS-PPA): Consensus-based recommendations for communication interventions across research and clinical settings.

Introduction: Interventions to treat speech-language difficulties in primary progressive aphasia (PPA) often use word accuracy as a highly comparable outcome. However, there are more constructs of importance to people with PPA that have received less attention.

Methods: Following Core Outcome Set Standards for Development Recommendations (COSSTAD), this study comprised: Stage 1 - systematic review to identify measures; Stage 2 - consensus groups to identify important outcome constructs for people with PPA (n = 82) and care partners (n = 91); Stage 3 - e-Delphi consensus with 57 researchers.

Influence of Peanut Consumption on the Gut Microbiome: A Randomized Clinical Trial.

Peanut consumption could impact cardiometabolic health through gut microbiota, a hypothesis that remains to be investigated. A randomized clinical trial in Vietnam evaluated whether peanut consumption alters gut microbiome communities. : One hundred individuals were included and randomly assigned to the peanut intervention and control groups.

Synthesis and Thermo-Selective Recycling of Diels-Alder Cyclopentadiene Thermoplastics.

Catalyst-free and reversible step-growth Diels-Alder (DA) polymerization has a wide range of applications in polymer synthesis and is a promising method for fabricating recyclable thermoplastics. The effectiveness of polymerization and depolymerization relies on the chemical building blocks, often utilizing furan as the diene and maleimide as the dienophile. Compared to the traditional diene-dienophile or two-component approach that requires precise stoichiometry, cyclopentadiene (Cp) can serve dual roles via self-dimerization.

Controlled Synthesis of a Homopolymer Network Using a Well-Defined Single-Component Diels-Alder Cyclopentadiene Monomer.

Cyclopentadiene is known for its high reactivity and propensity to dimerize, making monomer synthesis and polymerization notoriously challenging. In fact, despite its long history and compelling chemistry, only two reports have appeared in the literature since the first attempt to homopolymerize cyclopentadiene by Staudinger in 1926. Herein, we present a strategy not only to synthesize, isolate, and homopolymerize a well-defined tetracyclopentadiene monomer but also to de-cross-link the network homopolymer.

Normative Data for Healthy French-Speaking Persons Aged 80 Years and Older for the DTLA Language Screening Test.

Unlabelled: The Detection Test for Language Impairments in Adults and the Aged (DTLA) is a quick, sensitive, and standardized screening test designed to assess language disorders in adults and elderly people. The test was specifically developed to detect linguistic impairment associated with major neurocognitive disorders. In 2017, we established normative data on 545 healthy individuals between 50 and 80 years old from four French-speaking countries: Belgium, Canada (Quebec), France, and Switzerland.

Polyoxymethylene/silica/polylactic acid-grafted polyethylene glycol nanocomposites: structure, morphology, and mechanical properties and ozone and UV durability.

Polyoxymethylene (POM) is a semicrystalline thermoplastic that displays high tensile strength, thermal stability, and chemical durability. However, its widespread application is limited by its low elongation at break and thermal durability. In the present study, nanosilica (NS) and polylactic acid-grafted polyethylene glycol (PELA) were used as enhancement additives to improve the performance of POM homopolymer.

Detection Test for Language Impairments in Adults and the Aged-A New Screening Test for Language Impairment Associated With Neurodegenerative Diseases: Validation and Normative Data.

To date, there is no quick screening test that could be used during routine office visits to accurately assess language disorders in neurodegenerative diseases. To fill this important gap, we developed the Detection Test for Language impairments in Adults and the Aged (DTLA), a quick, sensitive, standardized screening test designed to assess language disorders in adults and the elderly individuals. In Study 1, we describe the development of the DTLA.

Inter-individual variability in discourse informativeness in elderly populations.

An increasing number of studies focus on discourse production in patients with neurodegenerative diseases and underline its clinical usefulness. However, if this is to be used as a clinical tool, one needs to consider how normal discourse varies within cognitively unimpaired elderly populations. In the current study, the aim has been to investigate discourse macrolinguistic variability.

Phenols as probes of chemical composition of graphene oxide.

Graphene oxide (GO) can be conveniently used as a starting material for the preparation of selective and sensitive electrochemical sensing systems. The amount of oxygen groups present on the material can be precisely tuned by reduction methodologies which allow the selection of the optimal C/O ratio for specific analytes. An electrochemical reduction procedure is used in this work to alter the oxygen content of the GO starting material and investigate the effects on the electrochemical detection of phenolic compounds selected with different hydroxyl groups: phenol, catechol, hydroquinone and phloroglucinol.

A new megastigmane sulphoglycoside and polyphenolic constituents from pericarps of Garcinia mangostana.

A megastigmane sulphoglycoside together with three phenolic compounds were isolated from the water-soluble fraction of the pericarps of Garcinia mangostana. The structure of the new compound was determined as 4-O-sulpho-β-d-glucopyranosyl abscisate (1) by spectroscopic data. Proanthocyanidin A2 (2) showed potent α-glucosidase inhibitory and DPPH scavenging activities with IC50 values of 3.

Knowledge, attitudes, practices and emotional reactions among residents of avian influenza (H5N1) hit communities in Vietnam.

Background: Awareness of individuals' knowledge and predicting their behavior and emotional reactions is crucial when evaluating clinical preparedness for influenza pandemics with a highly pathogenic virus. Knowledge, attitude, and practice (KAP) relating to avian influenza (H5N1) virus infection among residents in communities where H5N1 patients occurred in Vietnam has not been reported.

Methods And Principal Findings: Face-to-face interviews including KAP survey were conducted in Bac Kan province, located in the northeast mountainous region of Vietnam.

For a new look at 'lexical errors': evidence from semantic approximations with verbs in aphasia.

The ability to understand the similarity between two phenomena is fundamental for humans. Designated by the term analogy in psychology, this ability plays a role in the categorization of phenomena in the world and in the organisation of the linguistic system. The use of analogy in language often results in non-standard utterances, particularly in speakers with aphasia.