Publications by authors named "Thi Linh Giang Tran"
Cytotoxic effects of the standardized extract from Salisb. rhizomes via induction of mitochondria-mediated caspase-dependent apoptotic pathway and p21-mediated G0/G1 cell cycle arrest on human gastric cancer AGS cells.
Chinh Chung Doan Thanh Long Le Nguyen Quynh Chi Ho Thi Thuy Nguyen Nghia Quang Huy Hoang Thi Linh Giang Tran
J Toxicol Environ Health A
March 2025
Article Synopsis
- Salisb. is a traditional herb used to treat various diseases, including gastric cancer, but its specific effects on gastric cancer cells require further investigation.
- This study explored how a standardized extract of Salisb. rhizome induces cell death in gastric cancer AGS cells, primarily through apoptosis and cell cycle disruption.
- The extract's active compounds, curdione and germacrone, were shown to affect mitochondrial function and cell cycle regulatory proteins, highlighting their potential as anti-cancer agents.
Article Synopsis
- - Gagnep, a Vietnamese medicinal plant, has been studied for its chemical composition and anti-cancer properties, particularly focusing on its rhizome extract (CSE).
- - The study evaluated the cytotoxic effects of CSE on liver and breast cancer cells using different assays, finding significant cancer cell death while sparing normal cells, and showing a dose-dependent induction of apoptosis in specific cancer cell lines.
- - Key compounds identified in the extract included sesquiterpenes like germacrone, ar-turmerone, and curcumol, marking this research as the first to report on the anti-cancer activity of Gagnep's rhizomes.