Rapid and Efficient Dual Detection Of Zn Ions and Oxytetracycline Hydrochloride Using a Responsive Fluorescent "On-Off" Sensor Based on Simple Salen-Type Schiff Base Ligand.

This research has progressed to an effective detection chemosensor of zinc, aluminum ions and oxytetracycline hydrochloride antibiotic based on the fluorescence technique. A straightforward method utilizing microwave irradiation was employed to synthesize the salen-type Schiff base ligand N,N'-bis(salicylaldehyde)4,5-dichloro-1,2-phenylenediamine (HI), providing a good 70 % yield. In ethanol, the HI sensor demonstrated remarkable rapidity, selectivity, and sensitivity in detecting zinc ions.

Heptaellipside A, a rare new 2,28-bidesmosidic lupane-type saponin from the leaves of .

For the first time, phytochemical constituents of the leaves of were investigated. One rare new 2,28-bidesmosidic lupane-type saponin, named heptaellipside A (), along with four other lupane-type analogs () were purified by combining differently chromatographic methods. All of the separated compounds () were communicated for the first time from .

Synthesis, crystal structure and Hirshfeld surface analysis of 2-({5-[(naphthalen-1-yl)meth-yl]-4-phenyl-4-1,2,4-triazol-3-yl}sulfan-yl)-1-(4-nitro-phen-yl)ethanone.

The title compound, CHNOS, crystallizes in the monoclinic system, space group 2/, with = 4. The global shape of the mol-ecule is determined by the orientation of the substituents on the central 4-1,2,4-triazole ring. The nitro-phenyl ring, phenyl ring, and naphthalene ring system are oriented at dihedral angles of 82.

Exploration of Remarkably Potential Multitarget-Directed N-Alkylated-2-(substituted phenyl)-1-benzimidazole Derivatives as Antiproliferative, Antifungal, and Antibacterial Agents.

Improving lipophilicity for drugs to penetrate the lipid membrane and decreasing bacterial and fungal coinfections for patients with cancer pose challenges in the drug development process. Here, a series of new N-alkylated-2-(substituted phenyl)-1-benzimidazole derivatives were synthesized and characterized by H and C NMR, FTIR, and HRMS spectrum analyses to address these difficulties. All the compounds were evaluated for their antiproliferative, antibacterial, and antifungal activities.

Metal complexes of benzimidazole-derived as potential anti-cancer agents: synthesis, characterization, combined experimental and computational studies.

In this study, a series of 14 Cu (II), Zn (II), Ni (II) and Ag (I) complexes containing bis-benzimidazole derivatives were successfully designed and synthesized from 2-(1-benzimidazole-2-yl)-phenol derivatives and corresponding metal salt solutions. The compound structures were identified by FT-IR, H-NMR, powder X-ray diffraction and ESI-MS analyses, and the presence of the metal in the complexes was confirmed by ultraviolet-visible spectroscopy and ICP optical emission spectrometry. Electronic structure calculations were also carried out to describe the detailed structures in addition to the electronic absorption spectra of the ligands.

Synthesis and insight into the structure-activity relationships of 2-phenylbenzimidazoles as prospective anticancer agents.

In order to explore and develop new anticancer agents, three series of 2-phenylbenzimidazoles, 15-46, were condensed under simple and mild conditions using sodium metabisulfite as an oxidation agent and another series, 47-55, were obtained a reduction reaction using sodium borohydride. All the compounds synthesized were evaluated for their anticancer activities against three human cancer cell lines. The novel compound 38 was found to be the most potent multi cancer inhibitor against A549, MDA-MB-231, and PC3 cell lines (IC values 4.

Pegylated dendrimer and its effect in fluorouracil loading and release for enhancing antitumor activity.

Dendrimer, a new class of hyper-branched polymer with predetermined molecular weight, is being received much attention in nano biomedical applications such as anticancer drug delivery, gene therapy, disease diagnosis and etc. In this study, polyamidoamine (PAMAM)-based dendrimer generation 3.0 (G 3.

Preparation and properties of silver nanoparticles loaded in activated carbon for biological and environmental applications.

Silver nanoparticles colloid has been prepared by a modified sonoelectrodeposition technique in which a silver plate was used as the source of silver ions. This technique allows producing Ag nanoparticles with the size of 4-30 nm dispersed in a non-toxic solution. The Ag nanoparticles were loaded in a high surface activated carbon produced from coconut husk, a popular agricultural waste in Vietnam by thermal activation.