Open Partial Horizontal Laryngectomy in the Elderly: Oncological and Functional Outcomes.

Objectives: The aim of the present study was to investigate the oncological and functional prognostic implication of perioperative risk factors in the elderly patient who underwent open partial horizontal laryngectomy (OPHL).

Study Design: A single institution, retrospective case-cohort study.

Methods: The present study retrospectively reviewed the clinical charts of a cohort of 100 elderly laryngeal squamous cell carcinoma (LSCC) patients who underwent OPHL at our institution.

Reading mA marks in mRNA: A potent mechanism of gene regulation in plants.

Modifications to RNA have recently been recognized as a pivotal regulator of gene expression in living organisms. More than 170 chemical modifications have been identified in RNAs, with N-methyladenosine (mA) being the most abundant modification in eukaryotic mRNAs. The addition and removal of mA marks are catalyzed by methyltransferases (referred to as "writers") and demethylases (referred to as "erasers"), respectively.

Apolipoprotein E polymorphism in Vietnamese children and its relationship to plasma lipid and lipoprotein levels.

We investigated the frequency of apolipoprotein E (apoE) polymorphism and the effect of apoE polymorphism on plasma lipid and lipoprotein levels under different nutritional statuses in Vietnamese children living in urban and rural areas. Three hundred and forty-eight girls (aged 7 to 9 years) were randomly selected from urban and rural areas in southern Vietnam. Their apoE genotypes were analyzed by an Invader assay, and the plasma lipid and lipoprotein levels were determined by enzymatic methods using fasting blood samples.