Publications by authors named "Thi Chinh Nguyen"
infection is a major global health concern, linked to the development of various gastrointestinal diseases, including gastric cancer. To study the pathogenesis of and develop effective intervention strategies, appropriate animal pathogen models that closely mimic human infection are essential. This study focuses on the understudied hpEastAsia genotype in Southeast Asia, a region marked by a high infection rate.
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- The study investigates discrepancies in detecting African swine fever virus (ASFV) using conventional and real-time PCR methods, highlighting a potential issue with primer and probe mismatches.
- Results indicated that a single mismatch in the probe binding region could lead to false-negative results in real-time PCR, emphasizing the importance of precise primer design.
- The research calls for careful consideration of molecular diagnostic methods and updated ASFV sequence databases for effective epidemiological surveillance.
Genetic Characterisation of African Swine Fever Virus in Outbreaks in Ha Nam Province, Red River Delta Region of Vietnam, and Activity of Antimicrobial Products Against Virus Infection in Contaminated Feed.
J Vet Res
June 2020
Introduction: African swine fever (ASF) was officially reported in Vietnam in February 2019 and spread across the whole country, affecting all 63 provinces and cities.
Material And Methods: In this study, ASF virus (ASFV) VN/Pig/HaNam/2019 (VN/Pig/HN/19) strain was isolated in primary porcine alveolar macrophage (PAM) cells from a sample originating from an outbreak farm in Vietnam's Red River Delta region. The isolate was characterised using the haemadsorption (HAD) test, real-time PCR, and sequencing.