Publications by authors named "Thi Bich Phuong Nguyen"

Article Synopsis
  • In Viet Nam, a study utilizing the "Double X" strategy was implemented to diagnose tuberculosis (TB) by combining chest radiographs, computer-aided detection, and GeneXpert testing, revealing that many individuals with pulmonary TB might be asymptomatic.
  • The research analyzed the characteristics of symptomatic and asymptomatic participants, finding that over half of those with confirmed TB were subclinical, with particular demographic trends noted (e.g., older age groups, non-smokers).
  • Results suggested that computer-aided detection of specific radiographic abnormalities, such as fibrosis, could be effective in identifying subclinical TB cases, emphasizing its role in community TB screening efforts.
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Background: Afatinib is indicated for advanced-stage non-small-cell lung cancer (NSCLC) with Epidermal Growth Factor Receptor (EGFR) and uncommon mutations. However, real-world studies on this topic are limited. This study aimed to evaluate afatinib as first-line therapy for locally advanced and metastatic NSCLC with uncommon EGFR mutations.

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Background: This study aimed to evaluate the efficacy and side effects of first-line afatinib treatment in a real-world setting in Vietnam.

Methods: This retrospective study was conducted across nine hospitals in Vietnam. Advanced epidermal growth factor receptor (EGFR)-mutant non-small cell lung cancer (NSCLC) patients who received afatinib as first-line therapy between April 2018 and June 2022 were included, and patient medical records were reviewed.

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In Vietnam, chest radiography (CXR) is used to refer people for GeneXpert (Xpert) testing to diagnose tuberculosis (TB), demonstrating high yield for TB but a wide range of CXR abnormality rates. In a multi-center implementation study, computer-aided detection (CAD) was integrated into facility-based TB case finding to standardize CXR interpretation. CAD integration was guided by a programmatic framework developed for routine implementation.

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Staphylococcus warneri ISK-1 produces a lantibiotic, nukacin ISK-1. The nukacin ISK-1 gene cluster consists of at least six genes, nukA, -M, -T, -F, -E, and -G, and two open reading frames, ORF1 and ORF7 (designated nukH). Sequence comparisons suggested that NukF, -E, -G, and -H contribute to immunity to nukacin ISK-1.

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